|
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
Resistance to endocrine treatment in breast cancer cells was associated with SLC7A5- and LLGL2-dependent adaption to nutrient stress.
|
30996345 |
2019 |
|
Breast Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
Resistance to endocrine treatment in breast cancer cells was associated with SLC7A5- and LLGL2-dependent adaption to nutrient stress.
|
30996345 |
2019 |
|
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
CTD_human |
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.
|
28114269 |
2017 |
|
Breast Carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.
|
28114269 |
2017 |
|
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
Thereby, ZEB1 suppresses the expression of cell polarity factors, in particular of Lgl2, which we found reduced in colorectal and breast cancers.
|
18199550 |
2008 |
|
Breast Carcinoma
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The Heregulin (HGL) gene, encoding a ligand for a member of the ERBB receptor family, is located at 8p12-p22, in or close to a region frequently amplified in breast carcinoma.
|
7529049 |
1994 |
|
Neoplasm Metastasis
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.
|
28114269 |
2017 |
|
Neoplasm Metastasis
|
0.310 |
AlteredExpression
|
phenotype |
BEFREE |
We further show that retention of Lgl2 expression is critical for the epithelial phenotype and that its loss might be involved in metastasis.
|
18199550 |
2008 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.
|
28114269 |
2017 |
|
Mammary Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.
|
28114269 |
2017 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.
|
28114269 |
2017 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Forced expiratory volume function
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Whereas Lgl functions as a tumour suppressor in Drosophila<sup>1</sup>, the roles of mammalian LLGL1 and LLGL2 in cancer are unclear.
|
30996345 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Our analysis of published cancer dataset shows that many polarity genes, including PARD6B, SCRIB, PRKCI, DLG1, DLG2, DLG5 and LLGL2, are frequently amplified in multiple cancers raising the possibility that mammalian epithelia may have evolved to use polarity proteins in multiple ways where they may have tumor promoting functions.
|
29369778 |
2018 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The 5'-CpG islands of both miR-200 loci were found unmethylated and coupled to the expression of the corresponding miRNAs in human cancer cell lines with epithelial features, such as low levels of ZEB1/ZEB2 and high expression of E-cadherin, CRB3 and LGL2, while CpG island hypermethylation-associated silencing was observed in transformed cells with mesenchymal characteristics.
|
21874049 |
2012 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Thus, LLGL2 functions as a promoter of tumour growth and not as a tumour suppressor in ER<sup>+</sup> breast cancer.
|
30996345 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Whereas Lgl functions as a tumour suppressor in Drosophila<sup>1</sup>, the roles of mammalian LLGL1 and LLGL2 in cancer are unclear.
|
30996345 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our results suggest that Lgl2 loss occurs at an early stage of gastric carcinogenesis and contributes to GC progression.
|
24337435 |
2014 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
To determine whether the human giant larvae homolog 1 gene (Hugl-1/Llg1/Lgl1) exerts tumor suppressor effects in esophageal cancer.
|
23864775 |
2013 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our results placing Hugl-2 within the Snail network as well as its ability to suppress Snail carcinogenesis identifies Hugl-2 as a target molecule driving cascades, which may have preventative and therapeutic promise to minimize cancer progression.
|
22580609 |
2013 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
The 5'-CpG islands of both miR-200 loci were found unmethylated and coupled to the expression of the corresponding miRNAs in human cancer cell lines with epithelial features, such as low levels of ZEB1/ZEB2 and high expression of E-cadherin, CRB3 and LGL2, while CpG island hypermethylation-associated silencing was observed in transformed cells with mesenchymal characteristics.
|
21874049 |
2012 |
|
Ischemic stroke
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to test the association of four polymorphisms (rs1671021 in LLGL2, rs753307 in RUVBL2, rs6007897 and rs4044210 in CELSR1) previously identified as ischemic stroke (IS) risk factors in a phased GWAS performed on 6341 Japanese individuals [1].
|
21511255 |
2011 |
|
Ischemic stroke
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
After DNA sequencing of linkage disequilibrium blocks containing these SNPs, three tag SNPs (rs6007897 of CELSR1, rs1671021 of LLGL2, and rs1062708 of RUVBL2) and a nonsynonymous SNP (rs4044210 of CELSR1) were examined for their relation to ischemic stroke in subject panels B and C. Both rs6007897 (A-->G, Thr2268Ala) and rs4044210 (A-->G, Ile2107Val) of CELSR1 as well as rs1671021 (T-->C, Phe479Leu) of LLGL2 were significantly associated with ischemic stroke in subject panel B.
|
19403135 |
2009 |