|
Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A dozen were shown to possess improved properties, among which inhibition of YO-PRO-1/TO-PRO-3 uptake and IL1β release upon BzATP activation of the receptor and dampening signs of DSS-induced colitis on mice, in comparison with reference antagonist GSK1370319A.
|
31525963 |
2020 |
|
Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Regression analyses on echocardiography and serum labs revealed that LMNA variant carriers had dilated cardiomyopathy and primary renal disease.
|
31383942 |
2020 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our study suggested that bone metastasis is an important prognostic factor and superior than the presence of the IDC-P for PCa patients with Grade Group 5.
|
31734052 |
2020 |
|
Decreased drug resistance
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Moreover, lamin A/C knockdown also decreased drug resistance of suspension MDA-MB-231 cells, but the effect on drug resistance was less than that of ABCC3 knockdown.
|
31367898 |
2020 |
|
Dysferlinopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, four proteins (myosin light chain 1/3, skeletal muscle isoform; lamin A/C; ankyrin repeat domain 2; and eukaryotic translation initiation factor 5A-1) were inconsistently elevated in the dysferlinopathy samples.
|
31439488 |
2020 |
|
Cholangitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although the HPC niche in FHL resembles that described in hepatopathies in dogs and in feline lymphocytic cholangitis, the expression of K19, α-SMA, MAC387 and lamin is more variable in FHL, and a common pattern of activation could not be established.
|
29741464 |
2019 |
|
Immune System Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Expectedly, LFP-20 pre-treatment attenuated the LPS-mediated immune disorders in ileum.
|
30837028 |
2019 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Our findings establish lamin A/C as a key regulator of Th differentiation in physiological conditions and show it as a potential immune-regulatory target in IBD.
|
31372995 |
2019 |
|
Actinic keratosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These AKs were graded as PRO I in 18·6% of cases, PRO II in 30·5% and PRO III in 50·8%.
|
29526028 |
2019 |
|
Osteoporosis, Senile
|
0.010 |
Biomarker
|
disease |
BEFREE |
Better understanding of MSC differentiation regulated by lamin A/C could provide insights into pathogenesis of age-related osteoporosis.
|
30706289 |
2019 |
|
Sleep disturbances
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Individuals who sleep >7 hours/night with no trouble sleeping are 40% less likely to have severe periodontal disease (odds ratio [OR] = 0.6, P < 0.05), adjusting for age, sex, smoking status, FPL, education level, and dental visit.
|
31749207 |
2019 |
|
Circovirus Infections
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further identified the N-terminal 24RRR26 of Cap to be crucial for binding to p32, and mutation of these three arginine residues significantly weakened the replication and pathogenesis of PCV2 <i>in vivo</i> In summary, our findings highlight a critical role of p32 in the activation and recruitment of PKC-δ to phosphorylate lamin A/C and facilitate porcine circoviral nuclear egress, and they certainly help understanding of the mechanism of PCV2 replication.<b>IMPORTANCE</b> Circovirus infections are highly prevalent in mammalian and avian species.
|
31511386 |
2019 |
|
Neurologic Symptoms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Many patients with an LMNA mutation have neurologic symptoms by their 30s and develop progressive cardiac manifestations during the next decade.
|
31476771 |
2019 |
|
Caffeine related disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Spot urine samples obtained 6 hours following 200-mg caffeine administration were used to determine caffeine metabolite ratios (CMRs); blood samples were used to determine CYP1A2*1F (rs762551) and CYP1A2*1C (rs2069514) polymorphisms and the hormonal profile (estradiol, progesterone, and luteinizing and follicle-stimulating hormones) at EFP, LFP, and LP.
|
30591530 |
2019 |
|
Somatotropin deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Short stature in a boy with atypical progeria syndrome due to LMNA c.433G>A [p.(Glu145Lys)]: apparent growth hormone deficiency but poor response to growth hormone therapy.
|
31199775 |
2019 |
|
Anastomosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
LFP-HHD has the same principle of original HHD allowing for multiple tension-free well-vascularized biliary anastomoses.
|
31313146 |
2019 |
|
insulin resistance in diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Patients with LMNA (n = 22) or PPARG pathogenic variants (n = 7), leptin <12 ng/mL, and diabetes, insulin resistance, or high triglycerides.
|
31194872 |
2019 |
|
Contralateral breast cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
In 100 DCIS patients whose margin was negative by the polygon method, 5 IBTR (3 DCIS and 2 invasive ductal carcinoma [IDC]) and 10 CBC (6 DCIS and 4 IDC) cases were identified during a median follow-up of 7.6 years (range, 0.9-17.4).
|
31062495 |
2019 |
|
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lamin-A tended to be lower in ovarian cancer, and higher expression of lamin-A was associated with better survival.
|
30384980 |
2019 |
|
Attention deficit hyperactivity disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings provide novel evidence that ADHD reflects impaired EDC and enhanced IDC, and they reinforce the clinical relevance of distinguishing EDC and IDC in future studies.
|
30589304 |
2019 |
|
CRANIOMETAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the nonspecific myopathic histopathological changes and extremely rare minicore-like structures can make it challenging to differentiate between SELN-myopathy and congenital muscular dystrophies, such as Ullrich or lamin A/C-CMD.
|
30612914 |
2019 |
|
CAMPOMELIC DYSPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the nonspecific myopathic histopathological changes and extremely rare minicore-like structures can make it challenging to differentiate between SELN-myopathy and congenital muscular dystrophies, such as Ullrich or lamin A/C-CMD.
|
30612914 |
2019 |
|
Coronary Microvascular Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the nonspecific myopathic histopathological changes and extremely rare minicore-like structures can make it challenging to differentiate between SELN-myopathy and congenital muscular dystrophies, such as Ullrich or lamin A/C-CMD.
|
30612914 |
2019 |
|
aggressive cancer
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Intraductal carcinoma of the prostate (IDC-P) should be reported when present, because of its strong link with aggressive cancer.
|
30477882 |
2019 |
|
Early-Stage Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to evaluate expression and prognostic significance of lamin A/C in early-stage breast cancer.
|
30610489 |
2019 |