|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model.
|
30962539 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these data suggest that the assembly of LMO2 into complexes, via direct LDB1 interaction, is a potential molecular target that could be exploited in LMO2-driven leukemias resistant to existing chemotherapy regimens.
|
26598604 |
2016 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The proto-oncogene LIM-domain only 2 (lmo2) was traditionally considered to be a pivotal transcriptional regulator in hematopoiesis and leukemia.
|
27779255 |
2016 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LIM domain only-2 (LMO2) overexpression in T cells induces leukemia but the molecular mechanism remains to be elucidated.
|
25499232 |
2015 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Its importance in T cell neoplasia has been further emphasized by the recurrent findings of interstitial deletions of chromosome 11 near LMO2 and of LMO2 as a target of retroviral insertion gene activation during gene therapy trials for X chromosome-linked severe combined immuno-deficiency syndrome, both types of event leading to similar T cell leukaemia.
|
26108219 |
2015 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these results establish a regulatory hierarchy of HOX control of LMO2 in normal development, which can be resurrected during leukaemia development.
|
23708655 |
2013 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, application of GSCA to leukemic gene sets allowed us to predict the reactivation of blood stem cell control mechanisms as a likely contributor to LMO2 driven leukemia.
|
23220237 |
2013 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia.
|
22615488 |
2012 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We use real-time PCR analysis to show that LMO2 and BCL-2 expression is preferentially upregulated both in biopsy material from t(17;19) B-precursor ALL patients and lymphoid cell lines derived from t(17;19) leukemias.
|
21072044 |
2011 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
|
20093438 |
2010 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The lmo2 gene is a specific oncogene in T-cell leukemia, for its ectopic expression causes both increased pro-T-cell proliferation and differentiation arrest, leading to the onset of leukemia.
|
20731704 |
2010 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a mouse model of one such oncogene, LMO2, the cellular effect is to induce self-renewal of committed T cells in the thymus, which persist long-term while acquiring additional mutations and eventually giving rise to leukemia.
|
20861166 |
2010 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tauhese results identify a previously unrecognized nuclear role for JAK2 in the phosphorylation of H3Y41 and reveal a direct mechanistic link between two genes, jak2 and lmo2, involved in normal haematopoiesis and leukaemia.
|
19783980 |
2009 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The highly concordant nature of the genetic events giving rise to mouse and human leukemias with mutations at Lmo2 are an encouraging sign to those wanting to use mice to model human cancer and may help in designing safer methods for retroviral gene therapy.
|
19461887 |
2009 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These markers included various first- and second-hit genetic alterations (TCRD-LMO2 breakpoint regions, n = 2; TAL1 deletions, n = 3; Notch1 mutations, n = 1) and nononcogenic T-cell receptor rearrangements (n = 13) that were derived from leukemias of 16 children who were 1.5 to 11.2 years old at diagnosis of leukemia.
|
17557895 |
2007 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia.
|
15541480 |
2005 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia.
|
15541480 |
2005 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal translocations and leukaemia: a role for LMO2 in T cell acute leukaemia, in transcription and in erythropoiesis.
|
9209362 |
1997 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11).
|
1923511 |
1991 |