Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we systematically dissected the LMO2/LDB1-binding interface to investigate the role of this interaction in T-cell leukemia.
|
26598604 |
2016 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
Enforced expression of E47 has differential effects on Lmo2-induced T-cell leukemias.
|
25499232 |
2015 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
LMO2 induces T-cell leukemia with epigenetic deregulation of CD4.
|
24792354 |
2014 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.
|
24465765 |
2014 |
Leukemia, T-Cell
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We show that although Scl is dispensable for Lmo2-driven leukemia, Lyl1 is critical for all oncogenic functions of Lmo2, including upregulation of a stem cell-like gene signature, aberrant self-renewal of thymocytes, and subsequent generation of T-cell leukemia.
|
23926305 |
2013 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
Identification of DeltaEF1 as a novel target that is negatively regulated by LMO2 in T-cell leukemia.
|
20731704 |
2010 |
Leukemia, T-Cell
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Five X-linked severe combined immunodeficiency patients (SCID-X1) successfully treated with autologous bone marrow stem cells infected ex vivo with an IL2RG-containing retrovirus subsequently developed T-cell leukemia and four contained insertional mutations at LMO2.
|
19461887 |
2009 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion.
|
16260184 |
2006 |
Leukemia, T-Cell
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, two X-SCID patients treated by gene therapy to rescue T-cell lymphopoiesis developed T-cell leukemias with retroviral insertion into the LMO2 gene causing clonal T-cell proliferation.
|
14645513 |
2003 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia.
|
9001422 |
1997 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
BEFREE |
One of these, designated Rhom-2, is located on human chromosome 11 at band 11p13, where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene.
|
2034676 |
1991 |
Leukemia, T-Cell
|
0.400 |
Biomarker
|
disease |
CTD_human |
One of these, designated Rhom-2, is located on human chromosome 11 at band 11p13, where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene.
|
2034676 |
1991 |