Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein (a) [Lp(a)] is an independent risk factor for atherosclerosis-related events that is under strong genetic control (heritability = 0.68-0.98).
|
25575512 |
2015 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic vascular disease.
|
29912783 |
2018 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The apo(a) [apolipoprotein(a)] gene is responsible for variations in plasma lipoprotein(a), high levels of which are a risk factor for atherosclerosis and myocardial infarction.
|
14680477 |
2004 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Increased concentrations of low-density-lipoprotein (LDL)-cholesterol (LDL-C) and lipoprotein a (Lp(a)) are scientifically accepted, independent risk factors for the development of atherosclerosis.
|
26789774 |
2016 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a) and its position among other risk factors of atherosclerosis.
|
18198982 |
2008 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Defects in the low density lipoprotein receptor gene affect lipoprotein (a) levels: multiplicative interaction of two gene loci associated with premature atherosclerosis.
|
2524837 |
1989 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Nontraditional cardiovascular risk factors such as lipoprotein(a) (Lp(a)), the genetic polymorphisms of apolipoprotein(a), apolipoprotein E (ApoE), and apolipoprotein B (ApoB) increase the prevalence of atherosclerosis in end-stage renal disease (ESRD) through quantitative and qualitative alterations.
|
31119518 |
2019 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There is now significant evidence to support an independent causal role for lipoprotein(a) (Lp(a)) as a risk factor for atherosclerotic cardiovascular disease.
|
31783529 |
2019 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a) [Lp(a)] is a genetically determined risk factor for atherosclerotic vascular disease.
|
8546123 |
1996 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Apo A-I (Apolipoprotein A-I) Vascular Gene Therapy Provides Durable Protection Against Atherosclerosis in Hyperlipidemic Rabbits.
|
29122817 |
2018 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein (a) (Lp(a)) is a risk factor for atherosclerosis but its role in IRD with accompanying coronary artery disease (CAD) is still unclear.
|
31079089 |
2019 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Non-high-density (HDL)-cholesterol, low-density lipoprotein (LDL)-particle number, apolipoprotein B, lipoprotein(a) (Lp(a)), and small-dense (sdLDL) and large-buoyant (lbLDL) LDL-subfractions are emerging apo B-containing atherosclerotic cardiovascular disease (ASCVD) risk factors.
|
31311555 |
2019 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Elevated levels of plasma lipoprotein(a) [Lp(a)] are thought to be a risk factor for atherosclerosis and coronary heart disease.
|
11126727 |
2000 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Serum lipoprotein(a) [Lp(a)] levels are genetically determined and considered to be an independent risk factor for atherosclerosis.
|
7570736 |
1995 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis.
|
22898070 |
2012 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Despite being both the longest known and the most prevalent genetic risk marker for atherosclerotic cardiovascular disease (CVD), little progress has been made in agreeing a role for lipoprotein (a) [Lp(a)] in clinical practice and developing therapies with specific Lp(a)-lowering activity.
|
24977982 |
2014 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In 2010, more than 45 years after the initial discovery of lipoprotein(a) [Lp(a)] by Kare Berg, an European Atherosclerosis Society Consensus Panel recommended screening for elevated Lp(a) in people at moderate to high risk of atherosclerotic cardiovascular disease (CVD).
|
21749171 |
2011 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although lipoprotein(a) (Lp(a)) has been regarded as an independent risk factor for atherosclerotic cardiovascular disease (ASCVD), its predictive role in outcomes in stable coronary artery disease (CAD) has been undetermined.
|
31178022 |
2019 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, a cohort of 110 patients with established atherosclerotic cardiovascular disease (ASCVD) due to hypercholesterolemia or concomitant lipoprotein(a)-hyperlipoproteinemia, who received PCSK9 antibodies for the first time during routine care, were consecutively identified.
|
30817043 |
2019 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to determine whether lipoprotein(a) [Lp(a)], considered a causal risk factor for cardiovascular disease, primarily promotes thrombosis or atherosclerosis.
|
22516069 |
2012 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interest in lipoprotein (a) [Lp(a)] has exploded over the past decade with the emergence of genetic and epidemiological studies pinpointing elevated levels of this unique lipoprotein as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve disease (CAVD).
|
30732864 |
2019 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a) (Lp(a)) is a proatherogenic plasma lipoprotein and an independent risk factor for atherosclerotic cardiovascular disease.
|
28265881 |
2017 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
LDL-C is unquestionably causal in the development of atherogenesis and atherosclerotic cardiovascular disease, but new options are required to address triglyceride-rich lipoproteins and lipoprotein(a).
|
31060364 |
2019 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a) Lp(a) is a cholesterol-rich, LDL-like particle that is independently associated with an increased risk for ischemic heart disease, atherosclerosis, thrombosis, and stroke.
|
28608522 |
2018 |
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Associations of Lipoprotein(a) Levels With Incident Atrial Fibrillation and Ischemic Stroke: The ARIC (Atherosclerosis Risk in Communities) Study.
|
29246963 |
2017 |