LPA, lipoprotein(a), 4018

N. diseases: 340; N. variants: 49
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 GeneticVariation disease BEFREE Proprotein subtilisin kexin type 9 (PCSK9) and lipoprotein (a) [Lp(a)] levels are causative risk factors for coronary heart disease. 29103916 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Elevated plasma concentrations of lipoprotein(a) [Lp(a)] are an independent, and possibly causal, risk factor for atherothrombotic diseases including coronary heart disease. 30316749 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Moreover, BAX methylation was associated with smoking and lipoprotein A (Lp(a)) for individuals aged over 70 (CHD: smoking P = .012, Lp(a) P = .001; non-CHD: smoking P = .051, Lp(a) P = .004). 30681575 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE The relative expression of EGR1 in plasma of patients with CHD was negatively correlated with lipoprotein a [Lp(a)] and high sensitive C-reactive protein (hs-CRP) (r=-0.394 and -0.524, P<0.05), and the relative expression of CD69 in peripheral blood was positively correlated with [Lp(a)] and hs-CRP (r=0.352 and 0.402, P<0.05). 30783476 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Lipoprotein(a) and coronary artery disease in Chinese postmenopausal female patients: a large cross-sectional cohort study. 31315919 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Lipoprotein(a) and Cardiovascular Outcomes in Patients With Coronary Artery Disease and Prediabetes or Diabetes. 31076417 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Association of lipoprotein(a) and coronary artery disease in 1003 patients with stage 3-5 chronic kidney disease undergoing coronary angiography. 30585793 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 AlteredExpression disease BEFREE Levels of Lipoprotein (a) in patients with coronary artery disease with and without inflammatory rheumatic disease: a cross-sectional study. 31079089 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Genetic LPA score, plasma Lp(a) concentrations, and observations of statin therapies on CHD outcomes. 31017618 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Finally, we investigated whether selection bias may explain a recently reported finding that lipoprotein(a) is not a causal risk factor for cardiovascular mortality in individuals with previous coronary heart disease. 30325422 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 GeneticVariation disease BEFREE A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population. 31186284 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Lipoprotein(a) and other ASCVD risk factors were measured at baseline (1996-1998) in the biracial Atherosclerosis Risk in Communities study; participants without prevalent ASCVD (coronary heart disease or stroke) were monitored ∼15 years for incident ASCVD events. 30685442 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 AlteredExpression disease BEFREE Prognostic value of lipoprotein (a) level in patients with coronary artery disease: a meta-analysis. 31286992 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Lipoprotein (a) and Low-density lipoprotein apolipoprotein B metabolism following apheresis in patients with elevated lipoprotein(a) and coronary artery disease. 30447089 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Impact of Lipoprotein (a) Levels on Long-Term Outcomes in Patients With Coronary Artery Disease and Left Ventricular Systolic Dysfunction. 30918220 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis. 30482443 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Blood samples were collected before angiography in 32 subjects (mean age 56 ± 8 years) with stable coronary heart disease (CHD) and elevated lipoprotein(a) (Lp(a), 94 ± 35 mg/dL). 30934954 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 GeneticVariation disease BEFREE <b>Objective:</b> The study tested whether cardiovascular corresponding LPA risk genotypes improve pre-eclampsia and coronary heart disease (CHD) risk prediction beyond conventional risk factors. 31113255 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 AlteredExpression disease BEFREE However, clinical impacts of lipoprotein(a) levels on adverse vascular events in patients with established coronary artery disease who are undergoing statin treatment have not been fully elucidated. 31577620 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 GeneticVariation disease BEFREE Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis. 29926099 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 GeneticVariation disease BEFREE Lipoprotein(a) [Lp(a)] is an enigmatic lipoprotein which has been identified as a causal risk factor for coronary heart disease and calcific aortic valve disease. 29990619 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 GeneticVariation disease BEFREE Elevated plasma lipoprotein(a) levels were associated with increased risk of cardiovascular events in Chinese patients with stable coronary artery disease. 29769559 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 GeneticVariation disease BEFREE In these patients, low adiponectin and high lipoprotein(a) levels are found which are known to be associated with endothelial dysfunction, atherosclerosis and coronary artery disease. 27007665 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE Lipoprotein(a) and apolipoprotein(a) isoform size: Associations with angiographic extent and severity of coronary artery disease, and carotid artery plaque. 29960898 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.500 Biomarker disease BEFREE The analysis was designed to explore the combined effects of LDL-cholesterol and lipoprotein(a) (Lp(a)) in predicting incident coronary heart disease (CHD) in senior citizens without prior CHD. 28583815 2018