|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
A modified algorithm with lipoprotein(a) added for diagnosis of familial hypercholesterolemia.
|
31436336 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Low-density lipoprotein cholesterol (LDL-C) level and lipoprotein(a) [Lp(a)] ≥ 50 mg/dL predict atherosclerotic cardiovascular disease (ASCVD) risk in adults with familial hypercholesterolemia (FH), but their role for children with FH is less clear.
|
30150142 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of the present study is to compare the predictive value of an LPA variant, rs10455872, as well as Lp(a) concentration on the prevalence of CVD and on the age of the first CVD event in a cohort of genetically confirmed heterozygous patients with familial hypercholesterolemia (FH).
|
31103339 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Familial hypercholesterolemia (FH) and elevated lipoprotein(a) [Lp(a)] are inherited disorders associated with premature atherosclerotic cardiovascular disease (ASCVD).
|
30846097 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic traits for familial hypercholesterolemia and high lipoprotein(a) concentrations apparently co-exist and are associated with a higher ASVCD risk than each alone.
|
31393421 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) concentration is associated with plasma arachidonic acid in subjects with familial hypercholesterolaemia.
|
31262370 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
SLC22A3 is associated with lipoprotein (a) concentration and cardiovascular disease in familial hypercholesterolemia.
|
30772277 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Baseline and on-statin treatment lipoprotein(a) levels for predicting cardiovascular events in patients with familial hypercholesterolemia.
|
31683090 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Until last year, only the LDLR and LPA genes were appreciated as loci within which clinically relevant CNVs contributed to familial hypercholesterolemia and variation in Lp(a) levels, respectively.
|
30664016 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study confirmed that the MFHS is a strong predictor of prevalent CVD in FH and that the addition of lipoprotein(a) offers a minor improvement in the discrimination of the score.
|
28801029 |
2018 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent literature involving CNVs and dyslipidemias has focused mainly on rare CNVs causing familial hypercholesterolemia, and a common CNV polymorphism as the major determinant of lipoprotein(a) plasma concentrations.
|
29303791 |
2018 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated lipoprotein(a) and familial hypercholesterolemia in the coronary care unit: Between Scylla and Charybdis.
|
29480541 |
2018 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The relation of lipoprotein (a) [Lp(a)] and proprotein convertase substilisin/kexin type 9 (PCSK9) levels to coronary artery disease (CAD) has been well established in the general population, while little is known about the association between Lp(a) or PCSK9 and atherosclerotic lesions of different artery sites in patients with familial hypercholesterolemia (FH).
|
30170223 |
2018 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to investigate the relation between lipoprotein(a) [Lp(a)] and proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations, and their complex, in patients with potential familial hypercholesterolemia (FH), depending on apo(a) phenotype.
|
30270088 |
2018 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lipoprotein(a) level associates with coronary artery disease rather than carotid lesions in patients with familial hypercholesterolemia.
|
29603377 |
2018 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Should we Consider Lipoprotein (a) in Cardiovascular Disease Risk Assessment in Patients with Familial Hypercholesterolaemia?
|
30317988 |
2018 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
to analyze the relationship between lipid disturbance, including lipoprotein(a) (Lp(a)) levels, and development of ischemic heart disease (IHD) in patients with familial hypercholesterolemia (FH).
|
29096862 |
2017 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the associations of lipoprotein (a) [Lp(a)] with the FH phenotype, genotype and roles of Lp(a) in determining CAD risk among patients with and without FH.
|
28351002 |
2017 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increasing attention has come upon the genetic disorders of familial hypercholesterolemia and elevated lipoprotein(a).
|
28429242 |
2017 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Depicting new pharmacological strategies for familial hypercholesterolaemia involving lipoprotein (a).
|
29029165 |
2017 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, when adjusting LDL cholesterol for lipoprotein(a) cholesterol content the corresponding values were 24 mg/dL for individuals unlikely to have familial hypercholesterolaemia, 22 mg/dL for those with possible familial hypercholesterolaemia, and 21 mg/dL for those with probable or definite familial hypercholesterolaemia (ptrend=0·46).
|
27185354 |
2016 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PCSK9 and lipoprotein (a) levels are two predictors of coronary artery calcification in asymptomatic patients with familial hypercholesterolemia.
|
27594539 |
2016 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gain-of-Function Mutations.
|
26632531 |
2016 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) [Lp(a)] increases CAD in FH, although the independence of this association relative to other CAD risk factors remains unclear.
|
26340131 |
2015 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the relationship between LDLR genotype and the plasma levels of PCSK9, LDL-C, and lipoprotein (a) (Lp(a)) in a large cohort of genetically defined FH heterozygotes (HeFH).
|
26371983 |
2015 |