LPA, lipoprotein(a), 4018

N. diseases: 340; N. variants: 49
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Antisense oligonucleotide therapy has shown some promise in treating stroke causes that are genetically determined and resistant to classic prevention approaches such as elevated lipoprotein (a) and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). 30635869 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Lipoprotein(a) and other ASCVD risk factors were measured at baseline (1996-1998) in the biracial Atherosclerosis Risk in Communities study; participants without prevalent ASCVD (coronary heart disease or stroke) were monitored ∼15 years for incident ASCVD events. 30685442 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Serum lipoprotein(a) and risk of hemorrhagic stroke among incident peritoneal dialysis patients: a large study from a single center in China. 31498021 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Previous studies have examined the association of lipoprotein(a) and risk of stroke; however, the results are conflicting. 31272552 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Serum lipoprotein (a) is associated with increased risk of stroke in Chinese adults: A prospective study. 31437611 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Objective- Increased Lp(a) [lipoprotein(a)] is associated with coronary heart disease risk, but links with stroke are less consistent. 30786745 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE In recent prospective studies, high Lp(a) [lipoprotein(a)] level is associated with high risk of stroke but low risk of Alzheimer disease. 31597550 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE High concentrations of plasma lipoprotein(a) [Lp(a)] have been inferred to be an independent risk factor for cardiovascular and cerebrovascular diseases, such as coronary artery diseases, restenosis, and stroke. 29064597 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Lipoprotein(a) Lp(a) is a cholesterol-rich, LDL-like particle that is independently associated with an increased risk for ischemic heart disease, atherosclerosis, thrombosis, and stroke. 28608522 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE This study aims to determine lipoprotein (a) [Lp(a)] levels in serum and to investigate their associations with stroke recurrence events in a 3-month follow-up study in patients with acute ischemic stroke (AIS). 28004340 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group GWASCAT Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. 24262325 2014
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 AlteredExpression group BEFREE Increased levels of lipoprotein(a) are known as an independent risk factor for atherosclerosis, heart disease, and stroke in man. 23546733 2013
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Various prothrombotic risk factors have been investigated in pediatric stroke including elevated homocysteine and lipoprotein (a), antithrombin, protein C and protein S deficiency, Factor V Leiden, Factor II G20210A and plasminogen activator inhibitor-1 4G/5G polymorphism. 23092062 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE The comparable strength of associations of the LPA score with coronary disease and peripheral vascular disease but not with stroke suggest that lipoprotein(a) may have effects on atherothrombotic vascular disease that are only relevant at specific sites. 21252144 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE High plasma concentrations of lipoprotein(a) [Lp(a), which is encoded by the APOA gene] increase an individual's risk of developing diseases, such as coronary artery diseases, restenosis, and stroke. 21804189 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Lipoprotein(a) [Lp(a)] is an established risk factor for coronary disease and stroke, but mechanisms underlying this association are unknown. 21078622 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Increased levels of lipoprotein(a) (Lp[a])are known independent risk factor for atherosclerosis, heart disease, and stroke in adults. 22187404 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Multiple regression analyses for all subjects (n=90) showed that being a stroke patient (p<0.0001), fibrinogen (p<0.0001) and lipoprotein(a) (p=0.0075) were independent predictors of clot permeability (model R2 0.79). 19942259 2010
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Valproic acid can increase lipoprotein(a) and decrease fibrinogen, which may increase the risk of stroke or other thrombotic events. 19135623 2009
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 AlteredExpression group LHGDN Effect of aspirin on lipoprotein(a) in patients with ischemic stroke. 17845920 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group LHGDN Lipoprotein (a) and stroke: a meta-analysis of observational studies. 17478739 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Most children with pediatric stroke have more than one risk factor, mainly vasculopathies or elevation of lipoprotein(a). 17675027 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 AlteredExpression group LHGDN Lipoprotein(a), fibrinogen and vascular mortality in an elderly northern Italian population. 17145597 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 AlteredExpression group LHGDN Serum lipoprotein(a) levels and apolipoprotein(a) isoform size and risk for first-ever acute ischaemic nonembolic stroke in elderly individuals. 16197951 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE At least 3 months after stroke, the concentrations of total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), apolipoprotein E (apoE), and lipoprotein (a) [lp(a)] were measured and LDL phenotypes and apoE isoforms were identified. 12972382 2003