LPA, lipoprotein(a), 4018

N. diseases: 340; N. variants: 49
Disease: Aortic valve calcification ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0428791
Disease: Aortic valve calcification
Aortic valve calcification 		0.160 GeneticVariation disease BEFREE The role of elevated Lp(a) levels and LPA Kringle IV type 2 (KIV-2) size polymorphism in influencing aortic valve calcification and stenosis development in patients with tricuspid aortic valve was recognized. 30099661 2019
CUI: C0428791
Disease: Aortic valve calcification
Aortic valve calcification 		0.160 GeneticVariation disease BEFREE In a model adjusted for several CVRF, the LPA rs10455872-G allele was associated with high Lp(a) levels and AVC. 31188921 2019
CUI: C0428791
Disease: Aortic valve calcification
Aortic valve calcification 		0.160 Biomarker disease BEFREE However, recent data have suggested that lipoprotein(a) (Lp(a)) may play a previously unknown but critical role in the progression of AS. 28814237 2017
CUI: C0428791
Disease: Aortic valve calcification
Aortic valve calcification 		0.160 Biomarker disease BEFREE Using a Mendelian randomization study design, it was demonstrated that the effect of this genetic variant is mediated by plasma lipoprotein (a) [Lp(a)], directly implicating elevations in Lp(a) as a cause of AV calcium and progression to AS. 26685327 2016
CUI: C0428791
Disease: Aortic valve calcification
Aortic valve calcification 		0.160 Biomarker disease BEFREE Lipoprotein(a) and oxidized phospholipids are key therapeutic targets in calcific aortic stenosis. 27205885 2016
CUI: C0428791
Disease: Aortic valve calcification
Aortic valve calcification 		0.160 GeneticVariation disease BEFREE One SNP in the lipoprotein(a) (LPA) locus (rs10455872) reached genomewide significance for the presence of aortic-valve calcification (odds ratio per allele, 2.05; P=9.0×10(-10)), a finding that was replicated in additional white European, African-American, and Hispanic-American cohorts (P<0.05 for all comparisons). 23388002 2013
CUI: C0428791
Disease: Aortic valve calcification
Aortic valve calcification 		0.160 GeneticVariation disease GWASCAT Genetic associations with valvular calcification and aortic stenosis. 23388002 2013
CUI: C0428791
Disease: Aortic valve calcification
Aortic valve calcification 		0.160 GeneticVariation disease GWASDB Genetic associations with valvular calcification and aortic stenosis. 23388002 2013