LPA, lipoprotein(a), 4018

N. diseases: 340; N. variants: 49
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1704436
Disease: Peripheral Arterial Diseases
Peripheral Arterial Diseases
0.160 GeneticVariation group GWASCAT Genome-wide association study of peripheral artery disease in the Million Veteran Program. 31285632 2019
CUI: C1704436
Disease: Peripheral Arterial Diseases
Peripheral Arterial Diseases
0.160 Biomarker group BEFREE Lipoprotein apheresis in patients with peripheral artery disease and lipoprotein(a)-hyperlipoproteinemia: 2-year follow-up of a prospective single center study. 29096834 2017
CUI: C1704436
Disease: Peripheral Arterial Diseases
Peripheral Arterial Diseases
0.160 AlteredExpression group BEFREE The highest ranked hazard ratios for continuous factors in coronary heart disease were those for age, total cholesterol, high-sensitivity troponin, NT-pro-BNP, cotinine, apolipoprotein A, and waist circumference (plus 10 more); in PAD they were age, high-sensitivity C-reactive protein, systolic blood pressure, expired carbon monoxide, cotinine, socioeconomic status, and lipoprotein (a) (plus 5 more). 28923990 2017
CUI: C1704436
Disease: Peripheral Arterial Diseases
Peripheral Arterial Diseases
0.160 Biomarker group BEFREE Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts. 24760552 2014
CUI: C1704436
Disease: Peripheral Arterial Diseases
Peripheral Arterial Diseases
0.160 Biomarker group BEFREE The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST [Trial of Org 10172 in Acute Stroke Treatment] subtypes) (effective sample size [n(e)] = 9,396); peripheral arterial disease (n(e) = 5,215); abdominal aortic aneurysm (n(e) = 4,572); venous thromboembolism (n(e) = 4,607); intracranial aneurysm (n(e) = 1,328); CAD (n(e) = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). 22898070 2012
CUI: C1704436
Disease: Peripheral Arterial Diseases
Peripheral Arterial Diseases
0.160 GeneticVariation group BEFREE The LPA gene C93T polymorphism influences plasma lipoprotein(a) levels and is independently associated with susceptibility to peripheral arterial disease. 17942087 2008
CUI: C1704436
Disease: Peripheral Arterial Diseases
Peripheral Arterial Diseases
0.160 AlteredExpression group BEFREE Moreover, the presence of high levels of lipoprotein(a) and another metabolic risk factor raised the likelihood of PAD symptoms (dyslipidemia and elevated lipoprotein[a]: odds ratio [OR], 29; 95% confidence interval [CI], 6.2 to 136.2; P <.0001; hyperhomocysteinemia and elevated lipoprotein[a]: OR, 37.7; 95% CI, 3.7 to 381.5; P <.0001). 15768007 2005