|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Elevated lipoprotein(a) [Lp(a)] is an independent risk factor for coronary artery disease (CAD).
|
30234895 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population.
|
31186284 |
2019 |
|
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
However, clinical impacts of lipoprotein(a) levels on adverse vascular events in patients with established coronary artery disease who are undergoing statin treatment have not been fully elucidated.
|
31577620 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Proprotein subtilisin kexin type 9 (PCSK9) and lipoprotein (a) [Lp(a)] levels are causative risk factors for coronary heart disease.
|
29103916 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) and Cardiovascular Outcomes in Patients With Coronary Artery Disease and Prediabetes or Diabetes.
|
31076417 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Those with evidence of CAD were significantly more likely to be male, inactive, diabetic and with a family history of CVD than participants without CAD.About 20% of patients had lipoprotein(a) (Lp(a)) concentrations above 106.9 nmol/L (fifth quintile).
|
31481563 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein (a) and Low-density lipoprotein apolipoprotein B metabolism following apheresis in patients with elevated lipoprotein(a) and coronary artery disease.
|
30447089 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population.
|
31186284 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
To study the associations of LPA variants with CAVS in a cohort of patients undergoing heart surgery and LPA with CAVS in patients with CAD vs those without CAD and to determine whether first-degree relatives of patients with CAVS and high lipoprotein(a) (Lp[a]) levels showed evidence of aortic valve microcalcification.
|
31141105 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein (a) (Lp(a)) is a risk factor for atherosclerosis but its role in IRD with accompanying coronary artery disease (CAD) is still unclear.
|
31079089 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although lipoprotein(a) (Lp(a)) has been regarded as an independent risk factor for atherosclerotic cardiovascular disease (ASCVD), its predictive role in outcomes in stable coronary artery disease (CAD) has been undetermined.
|
31178022 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls.
|
28705542 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association of lipoprotein(a) and coronary artery disease in 1003 patients with stage 3-5 chronic kidney disease undergoing coronary angiography.
|
30585793 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) and other ASCVD risk factors were measured at baseline (1996-1998) in the biracial Atherosclerosis Risk in Communities study; participants without prevalent ASCVD (coronary heart disease or stroke) were monitored ∼15 years for incident ASCVD events.
|
30685442 |
2019 |
|
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Elevated lipoprotein (a) level is an independent predictor of cardiac and cardiovascular events in CAD patients.
|
31286992 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) and coronary artery disease in Chinese postmenopausal female patients: a large cross-sectional cohort study.
|
31315919 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
External validation confirmed the association of the LPA risk allele with risk of AVS (OR 1.37; 95%CI 1.27-1.47), again with a higher effect size in those without CAD.
|
30482443 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, no statistically significant association was found between genetic polymorphisms of PSRC1 A>G, LPL S447X and LPA C>T and CAD.
|
30902787 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Finally, we investigated whether selection bias may explain a recently reported finding that lipoprotein(a) is not a causal risk factor for cardiovascular mortality in individuals with previous coronary heart disease.
|
30325422 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Estimation of the Required Lipoprotein(a)-Lowering Therapeutic Effect Size for Reduction in Coronary Heart Disease Outcomes: A Mendelian Randomization Analysis.
|
31017618 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Elevated lipoprotein (a) [Lp(a)] and coronary artery disease (CAD) risk has been renewed interested in recent years.
|
30894407 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Impact of Lipoprotein (a) Levels on Long-Term Outcomes in Patients With Coronary Artery Disease and Left Ventricular Systolic Dysfunction.
|
30918220 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Elevated lipoprotein(a) (Lp[a]) and low-density lipoprotein (LDL) cholesterol are important inheritable risk factors for premature coronary artery disease (CAD).
|
29703625 |
2019 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Elevated plasma concentrations of lipoprotein(a) [Lp(a)] are an independent, and possibly causal, risk factor for atherothrombotic diseases including coronary heart disease.
|
30316749 |
2019 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
High concentrations of plasma lipoprotein(a) [Lp(a)] have been inferred to be an independent risk factor for cardiovascular and cerebrovascular diseases, such as coronary artery diseases, restenosis, and stroke.
|
29064597 |
2018 |