|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Stepwise discriminant analysis revealed that in the whole diabetic population the PvuII genotype of the LPL gene was independently and significantly associated with CHD but its effect decreased when the plasma lipids were taken into account.
|
7669092 |
1995 |
|
Coronary heart disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The study thus indicated that genetic variation of APOB, LPL, CETP, and lecithin cholesterol acyl transferase (which is linked to HPA and CETP) may play an important role in the regulation of lipoprotein metabolism and could contribute to the risk of coronary artery disease.
|
8279486 |
1993 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the LPL gene is involved in the determination of lipoprotein profiles, the predisposition to CHD, and the severity of atherosclerosis.
|
8576640 |
1995 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common DNA polymorphisms at the lipoprotein lipase gene. Association with severity of coronary artery disease and diabetes.
|
8641022 |
1996 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two common coding sequence mutations of lipoprotein lipase (serine447-ter, producing a carboxy terminal truncation; and asp9-asn variants) were studied in 329 Caucasian subjects, of whom 243 had angiographic features of premature atheroscelerosis (220 with coronary artery disease; 23 with coronary and peripheral artery disease).
|
8835323 |
1995 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Allelic frequencies of polymorphic variants at the lipoprotein lipase gene locus on chromosome 8 have been measured in subjects with premature coronary heart disease and/or dyslipidemia.
|
8907213 |
1995 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Regulatory mutations in the human lipoprotein lipase gene in patients with familial combined hyperlipidemia and coronary artery disease.
|
9017514 |
1996 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Asn9 variant of lipoprotein lipase is associated with the -93G promoter mutation and an increased risk of coronary artery disease. The Regress Study Group.
|
9550358 |
1998 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein lipase gene mutations in coronary artery disease.
|
9627528 |
1998 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Relative contribution of low-density lipoprotein receptor and lipoprotein lipase gene mutations to angiographically assessed coronary artery disease among French Canadians.
|
9708657 |
1998 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common genetic variants of lipoprotein lipase and apolipoproteins AI-CIII that relate to coronary artery disease: a study in Chinese and European subjects.
|
9719626 |
1998 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of lipoprotein lipase gene polymorphisms with coronary artery disease.
|
10091829 |
1999 |
|
Coronary heart disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins.
|
10191298 |
1999 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, we found that the most frequent variant at this locus, involving a C-terminal truncation of two amino acids (Ser447X), was associated with both higher LPL activity and high density lipoprotein cholesterol (HDL-C) in patients with CHD.
|
10450862 |
1999 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The lipoprotein lipase D9N/-93G to T allele has a summary odds ratio of 2.03 (95% confidence interval 1.30-3.18), indicating a twofold increase in risk of coronary disease for carriers with this allelic variant.
|
10554701 |
1999 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The entire coding and boundary regions of LPL and HTGL genes were analyzed by direct sequencing in 20 patients with both LHDL/HTG and diagnosed CHD.
|
10729390 |
2000 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of the lipoprotein lipase gene have been associated with dyslipidemia and coronary artery disease.
|
10974229 |
2000 |
|
Coronary heart disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fifteen common polymorphic variants at six loci (apolipoproteins AI, B, CIII and E, hepatic lipase and lipoprotein lipase) involved in plasma lipid transport have been studied in 210 northern Spanish men, of whom 98 had proven coronary artery disease.
|
11171287 |
2001 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The somewhat different effects of the D9N and N291S polymorphisms on plasma lipids, and the absence of a clear effect of the N291S on CHD, raise the possibility that the effect of 9N carrier status might be mediated through effects on LPL function in addition to those influencing fasting plasma lipids.
|
11427211 |
2001 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several studies have recently reported the presence of a relationship between Ser447Stop mutation of LPL and coronary artery disease.
|
11441189 |
2001 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Ter447 variant of LPL is associated with decreased risk of brain infarction and coronary artery disease in our very elderly population.
|
11680797 |
2001 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease.
|
11683775 |
2001 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Influence of lipoprotein lipase serine 447 stop polymorphism on tracking of triglycerides and HDL cholesterol from childhood to adulthood and familial risk of coronary artery disease: the Bogalusa heart study.
|
11730816 |
2001 |
|
Coronary heart disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activity and concentration of lipoprotein lipase in post-heparin plasma and the extent of coronary artery disease.
|
12048130 |
2002 |
|
Coronary heart disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No direct association was found between the LPL Arg192-->Gln substitution polymorphism and CHD, but there is a significant positive correlation between the A/A genotype of the LPL gene and CHD associated with high triglyceride/lowed high density lipoprotein cholesterol.
|
12133533 |
2002 |