|
Hypercholesterolemia
|
0.680 |
AlteredExpression
|
disease |
BEFREE |
Abnormalities of lipid metabolism in NS include hypertriglyceridemia and hypercholesterolemia due to elevated apolipoprotein B-containing lipoproteins, decreased lipoprotein lipase and hepatic lipase activity, increased hepatic PCSK9 levels, and reduced hepatic uptake of high-density lipoprotein.
|
31302760 |
2019 |
|
Hypercholesterolemia
|
0.680 |
AlteredExpression
|
disease |
BEFREE |
The levels of LPL in the liver are low but they can be strongly induced by a high cholesterol diet or by synthetic ligands of Liver X Receptors (LXRs).
|
28576574 |
2017 |
|
Hypercholesterolemia
|
0.680 |
Biomarker
|
disease |
CTD_human |
Effects of long-term consumption of low doses of resveratrol on diet-induced mild hypercholesterolemia in pigs: a transcriptomic approach to disease prevention.
|
21852083 |
2012 |
|
Hypercholesterolemia
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
In proportional-hazard models, adjusted for age, sex, smoking, hypertension, and hypercholesterolemia, hyperinsulinemia, defined as the highest sex-specific insulin quartile, was significantly associated with incident IHD with a hazard ratio (95% confidence interval) of 1.44 (1.05-1.98), P=0.025, without the LPL variants in the model, and a hazard ratio of 1.42 (1.03-1.95), P=0.031, with the LPL variants included in the model.
|
20347446 |
2010 |
|
Hypercholesterolemia
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and hypercholesterolemia revealed that the 677C-->T (Ala222Val) polymorphism of MTHFR, the 1595C-->G (Ser447Stop) polymorphism of LPL, and the -108/3G-->4G polymorphism of IPF1 were significantly associated with the prevalence of myocardial infarction.
|
16894468 |
2006 |
|
Hypercholesterolemia
|
0.680 |
Biomarker
|
disease |
BEFREE |
Furthermore, increased LPL activity in male Tg WHHL rabbits also corrected hypercholesterolemia (544 +/- 52 in non-Tg versus 227 +/- 29 mg/dl in Tg, p < 0.01) and reduced body fat accumulation by 61% (323 +/- 27 in non-Tg versus 125 +/- 21ginTg, p < 0.01), suggesting that LPL plays an important role in mediating plasma cholesterol homeostasis and adipose accumulation.
|
14660566 |
2004 |
|
Hypercholesterolemia
|
0.680 |
AlteredExpression
|
disease |
BEFREE |
Previous studies using transgenic mice and rabbits have demonstrated that high level of LPL activity in adipose and skeletal muscle protects against diet-induced hypercholesterolemia and subsequently prevents aortic atherosclerosis.
|
15122303 |
2004 |
|
Hypercholesterolemia
|
0.680 |
AlteredExpression
|
disease |
BEFREE |
These results demonstrate that systemically increased LPL activity functions in the metabolism of all classes of lipoproteins, thereby playing a crucial role in plasma triglyceride hydrolysis and lipoprotein conversion, and that overexpression of LPL protects against diet-induced hypercholesterolemia and atherosclerosis.
|
11477088 |
2001 |
|
Hypercholesterolemia
|
0.680 |
Biomarker
|
disease |
BEFREE |
Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia.
|
8349676 |
1993 |
|
Hypercholesterolemia
|
0.680 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hypercholesterolemia
|
0.680 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|