|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Therefore, current meta-analysis suggested that the LPL S447X polymorphism is likely to be a protective factor in the development of hypertension.
|
28640651 |
2017 |
|
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Hypertension is associated with increased expression of FABP3, FAS, FN1, IL1R2, LPL, SERPINE1, TGFB1, and VCAM1 and decreased expression of SELPLG and SERPINEB2.
|
23337395 |
2014 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
CTD_human |
A custom rat and baboon hypertension gene array to compare experimental models.
|
22228705 |
2012 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association of the HindIII and S447X polymorphisms in LPL gene with hypertension and type 2 diabetes in Mexican families.
|
23089926 |
2012 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This meta-analysis demonstrated that LPL gene S447X variant was significantly associated with hypertension and showed no obvious relation with pregnancy-induced hypertension and blood pressure variation.
|
20596061 |
2011 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphism of S447X lipoprotein lipase (LPL) and the susceptibility to hypertension.
|
19664517 |
2009 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Logistic regression analysis after adjustment for age, sex, adiponectin and S447X polymorphism demonstrated that LPL mass was inversely associated with CHD in men and both genders (p=0.02), with hypertension confined to women (p=0.04) and with MS likelihood in both genders combined and women [odds ratio 1.51 (95% CI 1.14-2.00) for halving the likelihood].
|
19191728 |
2009 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Thus, focusing on the endophenotype--hypertension combined with elevated TG--we designed a family-based haplotype association study to explore its genetic connection with novel genetic variants of lipoprotein lipase gene (LPL), which encodes a major lipid metabolizing enzyme.
|
18649389 |
2009 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Thus, focusing on the endophenotype--hypertension combined with elevated TG--we designed a family-based haplotype association study to explore its genetic connection with novel genetic variants of lipoprotein lipase gene (LPL), which encodes a major lipid metabolizing enzyme.
|
18649389 |
2009 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The LPL S447X polymorphism also impacts on CHD risk through interaction with hypertension, and there was an additive action of these 2 polymorphisms and SBP on CHD risk (hazard ratio for 1 SD increase in SBP for combined genotypes 1.78 [1.30 to 2.45]).
|
17562973 |
2007 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In conclusion, we present evidence that combinations of SNPs in APOE and LPL identify subgroups of individuals at substantially increased risk of IHD beyond that associated with smoking, diabetes and hypertension.
|
17006673 |
2007 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
While there is no evidence for a significant association of several common lipoprotein-related genetic variants with carotid IMT, our results are consistent with the previously reported role of CETP and LPL genetic variants in cardiovascular risk and the possible modulation of the association between hypertension and carotid IMT by APOCIII Sst-1 variant.
|
16430904 |
2006 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
LHGDN |
While there is no evidence for a significant association of several common lipoprotein-related genetic variants with carotid IMT, our results are consistent with the previously reported role of CETP and LPL genetic variants in cardiovascular risk and the possible modulation of the association between hypertension and carotid IMT by APOCIII Sst-1 variant.
|
16430904 |
2006 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
LPL marker (p < 10(-12)) and the haplotypes containing its allele 1 (p < 0.0001) were also significantly associated with young hypertension by transmission disequilibrium test.
|
16132104 |
2005 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
LHGDN |
A study of lipoprotein lipase gene intron 8 polymorphisms in Chinese Han race essential hypertension patients.
|
15749185 |
2005 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The present study in the Chinese families with hypertension suggested that the LPL gene might influence lipid levels, especially TG metabolism.
|
15482260 |
2005 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
LHGDN |
LPL marker (p < 10(-12)) and the haplotypes containing its allele 1 (p < 0.0001) were also significantly associated with young hypertension by transmission disequilibrium test.
|
16132104 |
2005 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our indivisual single nucleotide polymorphism (SNP) analysis did not provide substantial evidence of an association between polymorphisms in the LPL gene and hypertension status and/or blood pressure levels in this cohort, but the more powerful haplotypes analysis suggested an association between the LPL gene and hypertension.
|
15253101 |
2004 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
LHGDN |
The S447X polymorphism of the lipoprotein lipase gene is associated with lipoprotein lipid and blood pressure levels in Chinese patients with essential hypertension.
|
15257172 |
2004 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Evidence for linkage and association of the markers near the LPL gene with hypertension in Chinese families.
|
12746411 |
2003 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Since dyslipidemia is a common finding in hypertensive patients, the LPL gene is a logical candidate gene that could contribute to the development of hypertension.
|
12862202 |
2003 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We conclude that the lipoprotein lipase locus and nearby regions do not appear to be linked to hypertension in Caucasians.
|
10100092 |
1999 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Recently, the reverse genetic approach revealed that some genetic variants, such as angiotensinogen, lipoprotein lipase, and alpha-adducin gene polymorphisms, increase the risk for hypertension.
|
9607391 |
1998 |