LPL, lipoprotein lipase, 4023

N. diseases: 290; N. variants: 116
Disease: Cardiomyopathies ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.340 AlteredExpression group BEFREE Dilated lipotoxic cardiomyopathy, thought to be the result of diabetes and severe obesity, has been modeled in several genetically altered mice, including animals with cardiac-specific overexpression of glycosylphosphatidylinositol (GPI)-anchored human lipoprotein lipase (LpL(GPI)). 18515784 2008
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.340 Biomarker group BEFREE Apolipoprotein B production reduces lipotoxic cardiomyopathy: studies in heart-specific lipoprotein lipase transgenic mouse. 14634011 2004
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.340 AlteredExpression group BEFREE Thus, lipoprotein lipase expressed on the surface of cardiomyocytes can increase lipid uptake and produce cardiomyopathy. 12569168 2003
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.340 Biomarker group BEFREE Our results indicate a critical role for PPARalpha in myocardial pump function and suggest that mouse models combining different genetic effects such as PPARalpha knockout mice overexpressing muscle LPL may be useful to study cardiomyopathies. 12594240 2003
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.340 Biomarker group CTD_human Lipolysis is an important determinant of isoproterenol-induced myocardial necrosis. 10533957 1999