LRP1, LDL receptor related protein 1, 4035

N. diseases: 252; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group BEFREE The large number of detected loci, chief among them TRPM8, PRDM16, and LRP1, have enabled a number of in silico analyses, which have shed light on the functional and tissue-level aspects of the common risk variants for migraine, including evidence for involvement of both vascular and neuronal mechanisms. 29478595 2018
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group GWASCAT Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. 27322543 2016
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 Biomarker group BEFREE Four of these genes (TRPM8, UFL1, FHL5 and LRP1) were located in close proximity to previously reported genome-wide significant SNPs for migraine, while two genes, TARBP2 and NPFF separated by just 259 bp on chromosome 12q13.13, represent a novel risk locus. 26660531 2016
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group BEFREE To further replicate the GWAS findings, we investigated the 3 variants rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8), and rs11172113 (12q13.3, LRP1) for their association with migraine in the Chinese Han population. 24666033 2014
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group BEFREE Five loci met stringent significance for association with migraine, among which four were selective for sub-classified migraine, including rs11172113 (LRP1) for MO. 24852292 2014
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group BEFREE We report significant influence of rs1835740, LRP1 rs11172113 and PRDM16 rs2651899 polymorphisms on migraine susceptibility in the North Indian population. 24266335 2014
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group GWASCAT Genome-wide meta-analysis identifies new susceptibility loci for migraine. 23793025 2013
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group GWASDB Genome-wide meta-analysis identifies new susceptibility loci for migraine. 23793025 2013
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group BEFREE Two out of three SNPs that showed genome-wide significant associations in the previous study: rs10166942 (near TRPM8) and rs11172113 (in LRP1) were significantly associated with migraine in the present study. 23294458 2013
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group BEFREE We also replicated associations at two previously reported migraine loci in or near TRPM8 and LRP1. 22683712 2012
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group GWASDB Genome-wide association analysis identifies susceptibility loci for migraine without aura. 22683712 2012
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group GWASCAT Genome-wide association analysis identifies susceptibility loci for migraine without aura. 22683712 2012
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 Biomarker group CTD_human TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology. 21666692 2011
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group BEFREE In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5 × 10(-6)) with migraine. 21666692 2011
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group GWASCAT TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology. 21666692 2011
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.480 GeneticVariation group GWASDB TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology. 21666692 2011