LTA, lymphotoxin alpha, 4049

N. diseases: 353; N. variants: 26
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE The aim of this study was to investigate the association between the +252A/G polymorphism in the LT-α gene and the risk of asthma by performing a meta-analysis. 22882567 2012
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE The TNFA -1031C>T and TNFA -308G>A polymorphisms were strongly associated with the risk of asthma (p = 0.007, and p = 0.000, respectively), but the TNFB +252A>G polymorphism was not (p = 0.6). 21271873 2011
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE This study investigated an LT-alpha-Ncol polymorphism in the first intron of the LT-alpha gene (LT-alpha-Ncol*1 allele, as a variant type; and LT-alpha-Ncol*2 allele), which may predispose individuals to asthma and atopy. 18947013 2008
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease LHGDN The results indicate that LT-alpha-Ncol*1 may be a risk factor for atopic asthma in Taiwanese children. 18947013 2008
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE Our results suggest that the variability of LT-alpha genotypes may have potential implications for individual susceptibility to asthma in atopic or in ever-smoking Chinese adults in Hong Kong. 17536219 2007
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker disease BEFREE Polymorphisms in the proinflammatory cytokine genes tumor necrosis factor-alpha (TNF) and lymphotoxin-alpha (LTA, also called TNF-beta) have been associated with asthma and atopy in some studies. 17450233 2007
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease LHGDN Our results suggest that the variability of LT-alpha genotypes may have potential implications for individual susceptibility to asthma in atopic or in ever-smoking Chinese adults in Hong Kong. 17536219 2007
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE A marginal association was also observed for LTA_NcoI polymorphism with asthma and TsIgE levels.Furthermore, analysis using HAPLO. 16728705 2006
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE Our results suggest that LTA is one of the genes that contributes to susceptibility to atopic asthma, and that the association of the TNF/LTA haplotypes to asthma may be defined by the polymorphism in the LTA promoter region in the Japanese population. 15969671 2005
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE We conclude that it is unlikely that the TNF -308 or LTA NcoI polymorphisms influence asthma susceptibility individually, but that this haplotype of variants may be functional or may be in linkage disequilibrium with other functional single-nucleotide polymorphisms. 15976383 2005
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE In an effort to discover polymorphism(s) in genes whose variant(s) have been implicated in asthma phenotypes, we examined the genetic effects of TNF (TNFA and TNFB) polymorphisms on asthma and total serum IgE level. 14681301 2004
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker disease BEFREE We did not find linkage to the candidate genes TNF-beta, FcER1beta and Il4R-alpha, except for weak support for linkage of the asthma phenotype to TNF-beta (MLS = 1.18). 12121185 2002
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE To determine whether polymorphisms in the 5' flanking region of the TNFA gene (-1031C/T, -863C/A, and -857C/T) and an NcoI polymorphism in the TNFB gene (LTA NcoI) are associated with the development of asthma, we performed transmission disequilibrium tests of families identified through children with atopic asthma. 12091169 2002
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE We determined TNFalpha-308 and LTalpha-NcoI genotypes in 511 individuals: 236 asthma cases and 275 non-asthmatic controls. 11896460 2002
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker disease BEFREE To elucidate the association of polymorphisms in the Fc epsilon R1-beta and LT alpha genes to IgE responses and asthma in a family-orientated rural population. 12047428 2002
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE DRB1* and DQB1* HLA class II, TCR-Valpha8.1, FcepsilonRI-beta Rsa I exon 7 and intron 2, TNF-beta (LTalpha-Nco I) and CD14, were tested for association with asthma and atopy by multiple regression analysis, in 5 families comprising 87 individuals. 11574751 2001
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE It was our objective to determine whether one of the following polymorphism locations linked with asthma is associated with the bronchial hyperresponsiveness to SO2 observed in some asthmatic patients: the beta2-adrenergic receptor, interleukin-4 (IL-4) receptor alpha subunit, Clara cell secretory protein (CC16), TNF-alpha gene promoter, and first intron of the lymphotoxin alpha (LT-alpha) gene. 11258696 2001
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease BEFREE In this study we tested the hypothesis that two such polymorphisms, lymphotoxin alpha NcoI B*1 and -308 TNF2 may be components of the genetic predisposition to asthma. 10469028 1999