LTA, lymphotoxin alpha, 4049

N. diseases: 353; N. variants: 26
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.200 GeneticVariation disease BEFREE Association of lymphotoxin alpha polymorphism with type 1 diabetes in a Tunisian population. 24233435 2014
Diabetes Mellitus, Insulin-Dependent
0.200 GeneticVariation disease BEFREE The present study found an association of the TNF/LTA gene region with type 1 diabetes. 19167443 2009
Diabetes Mellitus, Insulin-Dependent
0.200 Biomarker disease BEFREE TNF-alpha/LTalpha T1DM-susceptible (-308G/+249G) and protective (-308G/+249A) haplotypes were identified. 17989340 2008
Diabetes Mellitus, Insulin-Dependent
0.200 Biomarker disease BEFREE The Th1 cytokines IFN-gamma and TNF-beta, secreted both spontaneously and by GAD(65)- and mitogen stimulation, were seen to a higher extent in high-risk children than in children newly diagnosed with T1D. 17315139 2007
Diabetes Mellitus, Insulin-Dependent
0.200 GeneticVariation disease GWASDB A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. 17632545 2007
Diabetes Mellitus, Insulin-Dependent
0.200 GeneticVariation disease BEFREE Initially, association with T1D was seen for LT-alpha A1069G (intron A, p=0.011, rs909253) and TNF G(-308)A (p<1x10(-5), rs1800629), but no association was observed for TNF G(-238)A (rs361525). 17174749 2006
Diabetes Mellitus, Insulin-Dependent
0.200 GeneticVariation disease BEFREE Then, we investigated AIF-1, TNF, and LT-alpha gene polymorphisms in 165 patients with type 1 diabetes, consisting of 90 patients with young-onset type 1 diabetes, 75 patients with adult-onset type 1 diabetes, and 200 control patients. 12559634 2003
Diabetes Mellitus, Insulin-Dependent
0.200 GeneticVariation disease BEFREE TNFA-TNFB haplotypes modify susceptibility to type I diabetes mellitus independently of HLA class II in a Moroccan population. 12622777 2003
Diabetes Mellitus, Insulin-Dependent
0.200 GeneticVariation disease BEFREE TNFB gene polymorphism in insulin-dependent diabetes mellitus: association with HLA-DR alleles. 9587743 1998
Diabetes Mellitus, Insulin-Dependent
0.200 GeneticVariation disease BEFREE A study of the microsatellite TNFa region close to the LTA gene showed that the presence of the TNFa1 allele in HLA-(DR3) subjects was associated with increased risk of IDDM. 9342542 1997
Diabetes Mellitus, Insulin-Dependent
0.200 Biomarker disease BEFREE The segregation of these alleles has been associated with levels of TNF alpha or TNF beta production in systemic lupus erythematosis (SLE), insulin-dependent diabetes mellitus (IDDM) and in healthy control individuals. 9098456 1994
Diabetes Mellitus, Insulin-Dependent
0.200 Biomarker disease BEFREE Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus. 8093442 1993
Diabetes Mellitus, Insulin-Dependent
0.200 GeneticVariation disease BEFREE This study suggests an association between the 10.5 kb TNF-beta allele and IDDM, and demonstrates an association between monokine responses and TNF-beta genotypes.(ABSTRACT TRUNCATED AT 400 WORDS) 1996407 1991
Diabetes Mellitus, Insulin-Dependent
0.200 GeneticVariation disease BEFREE Tumour necrosis factor-beta polymorphism is unlikely to determine susceptibility to type 1 (insulin-dependent) diabetes mellitus. 1682200 1991