|
Endometrioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis.
|
22138541 |
2012 |
|
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.
|
21081473 |
2011 |
|
Hepatitis, Toxic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver.
|
20935161 |
2010 |
|
Drug-Induced Liver Disease
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver.
|
20935161 |
2010 |
|
Hepatitis, Drug-Induced
|
0.300 |
Biomarker
|
disease |
CTD_human |
Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver.
|
20935161 |
2010 |
|
Drug-Induced Acute Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver.
|
20935161 |
2010 |
|
Chemical and Drug Induced Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver.
|
20935161 |
2010 |
|
Chemically-Induced Liver Toxicity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver.
|
20935161 |
2010 |
|
Spontaneous abortion
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Early Pregnancy Loss
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Neoplasms, Experimental
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Differential induction of Cyp1a1, Cyp1b1, Ahd4, and Nmo1 in murine skin tumors and adjacent normal epidermis by ligands of the aryl hydrocarbon receptor.
|
9496914 |
1998 |
|
Cutaneous Melanoma
|
0.120 |
AlteredExpression
|
disease |
BEFREE |
In contrast, the cytoplasmic expression of HIF-1β was higher in primary cutaneous melanoma than in intradermal nevi (p=0.001).
|
31594284 |
2019 |
|
Cutaneous Melanoma
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
|
30429480 |
2018 |
|
Cutaneous Melanoma
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
In supplementary meta-analyses derived from genome-wide association studies, one additional locus located 11 kb upstream of ARNT (chromosome 1q21) showed genome-wide statistical significance with CM.
|
25407435 |
2015 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program.
|
31451708 |
2019 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, restoring the expression of HIF-1β could partly abolish miR-107-mediated tumor suppression in ES cells.
|
29075999 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Reduction of tumor basal cells was restored by knockdown of aryl hydrocarbon receptor nuclear translocator (ARNT) that interacted with SIM2.
|
29427302 |
2018 |
|
Malignant melanoma of skin of upper limb
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
|
30429480 |
2018 |
|
Malignant melanoma of skin of lower limb
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
|
30429480 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expressions of TRIP11 and HIF-1β correlated with tumor grades.
|
29022645 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that ARNT may play a positive role during tumor growth (either in early-stage tumor growth or in organ metastases), but plays a negative role in tumor migration and invasion.
|
25839165 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Under hypoxic conditions, silencing of HIF-1β expression suppressed tumor cell growth and regulated the expression of tumor growth-related factors, such as vascular endothelial growth factor, epidermal growth factor, and hepatocyte growth factor.
|
25068796 |
2014 |