|
Hepatocarcinogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings highlight the complex regulatory network of miR-122 expression and its significance in hepatocarcinogenesis.
|
31561740 |
2020 |
|
Hepatocarcinogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Collectively, the findings of the present study may provide insight into the mechanistic role of HBV infection in modulating the expression of miR‑122, which targets the 3'UTR of APOBEC2 mRNA, subsequently inducing liver carcinogenesis.
|
31485598 |
2019 |
|
Hepatocarcinogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Collectively, our results suggest that HOTAIR epigenetically suppresses miR-122 expression via DNA methylation, leading to activation of Cyclin G1 and promotion of tumorigenicity in HCC, which provide new insight into the mechanism of HOTAIR-mediated hepatocarcinogenesis via suppressing miR-122.
|
30195653 |
2018 |
|
Hepatocarcinogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By comparing the signal transduction pathways involved in the identified core GENs, we found that the hepatocarcinogenesis through NAFLD&NASH was induced through DNA methylation of <i>HIST2H2BE</i>, <i>HSPB1</i>, <i>RPL30</i>, and <i>ALDOB</i> and the regulation of miR-21 and miR-122, and the hepatocarcinogenesis through PBC&PSC was induced through DNA methylation of <i>RPL23A</i>, <i>HIST2H2BE</i>, <i>TIMP1</i>, <i>IGF2</i>, <i>RPL30</i>, and <i>ALDOB</i> and the regulation of miR-29a, miR-21, and miR-122.
|
30344796 |
2018 |
|
Hepatocarcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of low values of circulating miR-152 is a potentially interesting marker of hepatocarcinogenesis in HCV+ patients, in contrast to miR-122, which varies according to hepatocyte damage.
|
28512857 |
2018 |
|
Hepatocarcinogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The biological roles of microRNAs (miRNAs) have been extensively studied. miRNA122 represents more than half of the miRNAs expressed in the liver and has various physiological and pathological functions, which include enhancing hepatitis virus replication, regulating lipid metabolism and suppressing hepatocellular carcinoma. miRNAs, whether globally or individually, have been linked with hepatocarcinogenesis.
|
27225852 |
2017 |
|
Hepatocarcinogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Restoration of miR-122 levels through delivery of agomir-122 suppressed DEN-induced hepatocarcinogenesis in mice.
|
26933995 |
2016 |
|
Hepatocarcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, GEM of miR-122 and miR-221 provided new approaches for better understanding of the in vivo functions of microRNA in hepatocarcinogenesis.
|
26259234 |
2015 |
|
Hepatocarcinogenesis
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Our study suggests that suppression of miR-122 induced by HBV infection, leads to the inactivation of IFN expression, which in turn enhances HBV replication, contributing to viral persistence and hepatocarcinogenesis.
|
25766860 |
2015 |
|
Hepatocarcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-122 (miR-122), a mammalian liver-specific miRNA, has been reported to play crucial roles in the control of diverse aspects of hepatic function and dysfunction, including viral infection and hepatocarcinogenesis.
|
25422324 |
2015 |
|
Hepatocarcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that silencing of miR-122 is an early event during hepatocarcinogenesis from NASH, and that miR-122 could be a novel molecular marker for evaluating the risk of HCC in patients with NASH.
|
25117675 |
2014 |
|
Hepatocarcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Can tobacco use promote HCV-induced miR-122 hijacking and hepatocarcinogenesis?
|
23218444 |
2013 |
|
Hepatocarcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis.
|
22820290 |
2012 |
|
Hepatocarcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The data demonstrate that miR-122 plays an important role in HBV-related hepatocarcinogenesis by targeting NDRG3.
|
21725618 |
2011 |
|
Hepatocarcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The miR-122 regulatory circuitry and its implication in hepatocarcinogenesis were identified using livers of different development stages, human hepatocellular carcinoma (HCC) tissues and cell lines, and aflatoxin B₁ (AFB₁)-transformed cells.
|
21038412 |
2010 |
|
Hepatocarcinogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results imply that aberrant expression of miR-122 may contribute to hepatocarcinogenesis.
|
19891584 |
2009 |
|
Hepatocarcinogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the role of miR-122 and cyclin G1 expression in hepatocarcinogenesis and in response to treatment with doxorubicin and their relevance on survival and time to recurrence (TTR) of HCC patients.
|
19584283 |
2009 |
|
Hepatocarcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the downregulation of miR-122 is associated with hepatocarcinogenesis and could be a potential biomarker for liver cancers.
|
16924677 |
2006 |