|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The expression of miR-210, miR-21 and miR-126 was performed using qRT-PCR in adenocarcinoma (no = 35), adenomas (no = 51), and neoplasm free controls (no = 101).
|
30357530 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
An increase in miR-200b was correlated with high-risk tumors (p = 0.01) while miR-126 overexpression was associated with Fuhrman's low grade (p = 0.03).
|
29202733 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
microRNA-126 (miR-126) has been reported to play tumor suppressor roles in various types of cancers.
|
26239517 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo inhibition of miRNA-144 or miRNA-126 decreases adipocyte-induced tumour growth.
|
31138258 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer.
|
19375957 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, the present study demonstrated that miR-126 acts as a tumor suppressor in OSCC cells, partially at least via the downregulation of EGFL7.
|
24789258 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MiR126 affects mitochondrial energy metabolism, resulting in MM tumor suppression.
|
24444362 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MiR-126 was reported to act as a tumor suppressor by targeting the Crk gene, or as an oncogene by targeting the SOX2 gene in gastric cancer.
|
24969300 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our results suggest that miR-126 is a tumor suppressor by sensitizing GC cells to chemotherapy and provide a potential therapeutic approach in cancer treatment.
|
27622325 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrated the responsibility of the circuitry connecting the oncomiR-221&222 with the tumor suppressors miR-126&126* in melanoma development and progression.
|
26434590 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Among the microRNAs (miRNAs) that control different cellular processes, miR-24, miR-126 and miR-365 were shown to regulate cell cycle progression and apoptosis in various types of tumors.
|
24153013 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We report here that miR-126/miR-126(*), a microRNA pair derived from a single precursor, independently suppress the sequential recruitment of mesenchymal stem cells and inflammatory monocytes into the tumour stroma to inhibit lung metastasis by breast tumour cells in a mouse xenograft model. miR-126/miR-126(*) directly inhibit stromal cell-derived factor-1 alpha (SDF-1α) expression, and indirectly suppress the expression of chemokine (C-C motif) ligand 2 (Ccl2) by cancer cells in an SDF-1α-dependent manner. miR-126/miR-126(*) expression is downregulated in cancer cells by promoter methylation of their host gene Egfl7.
|
23396050 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9.
|
22064652 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, these results demonstrated that miR-126 acts as a tumor suppressor by inactivating RhoA signaling via CXCR4 in colon cancer.
|
27517626 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The present study, to the best of our knowledge, is the first to report that miR-126 may serve tumor suppressor roles by inducing G<sub>1</sub> cell cycle arrest and suppressing invasion in ovarian cancer cells, at least in part by targeting VEGF expression.
|
29552211 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we show that the tumor suppressor miR-126, which is located within an intron of the EGFL7 gene, is downregulated in cancer cell lines and in primary bladder and prostate tumors.
|
19116145 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor xenograft model in nude mice was utilized to evaluate the influence of miR-126 on tumor growth.
|
27611944 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In term of miR-126, our results showed that miR-126 was associated with tumor stage and lymph nodes metastasis (P<0.05).
|
26823832 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of miR-126 as "tumor suppressor" was confirmed by using a tumor formation model <i>in vivo</i>.
|
31245291 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
After 6 weeks, the tumor volume in the miR-126 inhibitor group was significantly increased, while that in the MTCP1 siRNA group was significantly decreased.
|
30233082 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, the results from our study suggested that miR-126 could suppress tumor growth and tumor angiogenesis of GC through VEGF-A signaling, and it is a novel potential therapeutic target for GC.
|
25428912 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrated that miR-126-mediated tumor suppression might be partly dependent on AKT and ERK1/2 signaling pathways.
|
24189753 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, we demonstrated that the loss of tumor suppressor miR-126 in hepatitis B virus-related hepatocellular carcinoma cells contributes to the development of metastases through the upregulated expression of its target gene, ADAM9.
|
28639884 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, we identified that miR-126 suppresses tumor growth and metastasis in GC by targeting SRPK1.
|
29510776 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our data indicate that miR-126 functions as a tumor suppressor in OS, which exerts its activity by suppressing the expression of Sox2.
|
24384842 |
2013 |