|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, our study demonstrates that miR-127 functions as a tumor and metastasis suppressor in triple-negative breast cancer and that delivery of miR-127 may hold promise as a novel therapy.
|
31694904 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cells transfected with mir-127-3p and miR-376a-3p showed reduced tumor take rates and tumor volumes and a significant decrease of the cumulative tumor volumes to 41% and 54% compared to wildtype cells.
|
31847321 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MiRNAs are short ncRNAs which act as tumor suppressor (i.e., miR-15, miR-16, let-7, and miR-127) or oncogene (i.e., miR-155, miR-17-92, miR-21, miR-125b, miR-93, miR-143-p3, miR-196b, and miR-223) in leukemia.
|
30515779 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ITGA6 was proved to be the downstream target gene of miR-127-3p and functioned as a tumor promotor in OS, while miR-127-3p restrained deterioration of OS by suppressing cell viability, reducing migration and invasion, and promoting apoptosis.
|
29573114 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Comparison between primary tumors and metastases revealed an overlap only in pancreatic (miR-127) and ileal tumors (let-7g, miR-200a and miR-331).
|
29983867 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results indicate that re-expression of miR-127-3p and miR-376a-3p induces a strong tumor suppressor effect in GCTSC, which is partially mediated via COA1 and PDIA6.
|
28866093 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Subsequent BAG5 upregulation ameliorated the tumor-suppressive effects of miR-127-3p overexpression in EOC.
|
27571744 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MiR-127 is downregulated and acting as a tumor suppressor in pancreatic carcinoma.
|
27571739 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, the results revealed that miR-127-3p acts as a tumor suppressor and that its down-regulation in cancer may contribute to OS progression and metastasis, suggesting that miR-127-3p could be a potential therapeutic target in the treatment of OS.
|
26707641 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results suggest that miR-127 is downregulated and acting as tumor suppressor in ESCC.
|
27645894 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
miR-127 plays a tumor-suppressor role and can serve as a potential diagnostic biomarker for HCC.
|
24854842 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7.
|
24604520 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our results showed that miR-433 and miR-127 might act as tumor suppressors in GC, and it may provide novel diagnostic and therapeutic options for human GC clinical operation in the near future.
|
23880861 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data suggest that miR-127 may function as a tumor suppressor that modulates the oncogene BCL6.
|
24282530 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It has recently been shown that miR-127 and miR-124a, two putative tumor suppressor miRNAs, are methylated in tumor cells.
|
17581274 |
2007 |