MIR127, microRNA 127, 406914

N. diseases: 105; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.040 Biomarker disease BEFREE Transfection of osteosarcoma cells (<i>n</i> = 6) with miR-127-3p and miR-376a-3p mimics significantly inhibited proliferation and reduced the colony formation capacity of these cells. 31847321 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.040 Biomarker disease BEFREE ITGA6 was proved to be the downstream target gene of miR-127-3p and functioned as a tumor promotor in OS, while miR-127-3p restrained deterioration of OS by suppressing cell viability, reducing migration and invasion, and promoting apoptosis. 29573114 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.040 Biomarker disease BEFREE Knockdown of lncRNA MEG3 inhibits viability, migration, and invasion and promotes apoptosis by sponging miR-127 in osteosarcoma cell. 28636101 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.040 Biomarker disease BEFREE Overall, the results revealed that miR-127-3p acts as a tumor suppressor and that its down-regulation in cancer may contribute to OS progression and metastasis, suggesting that miR-127-3p could be a potential therapeutic target in the treatment of OS. 26707641 2016