MIR127, microRNA 127, 406914

N. diseases: 105; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 AlteredExpression phenotype BEFREE miR-127 is downregulated in breast cancer, where it has been shown to suppress the proliferation, migration and invasion of breast cancer cells. 31694904 2020
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 Biomarker phenotype BEFREE The association between miR-127 and Wnt7a expression was negatively correlated in GC tissues. miR-127 mimic in the two GC cell lines markedly curbed cell migration and invasion, while inhibition of miR-127 showed the opposite effect. 30867752 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 Biomarker phenotype BEFREE MiR-127-3p targeted KIF3B to inhibit the development of OSCC through suppressing cell proliferation, migration and invasion. 30720171 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 Biomarker phenotype BEFREE Hsa-mir-127 impairs survival of patients with glioma and promotes proliferation, migration and invasion of cancerous cells by modulating replication initiator 1. 29979259 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 AlteredExpression phenotype BEFREE In lentivirus-infected capan-1 and PANC-1 cells, miR-127 overexpression significantly inhibited cancer progression, cell-cycle transition and invasion in vitro, as well as tumorigenicity in vivo. 27571739 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 Biomarker phenotype BEFREE SETD8 was identified as a direct target of miR-127-3p, and SETD8 expression decreased post miR-127-3p overexpression, while SETD8 overexpression could reverse the potential influence of miR-127-3p on the migration and invasion of OS cells. 26707641 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 AlteredExpression phenotype BEFREE Lentiviral-mediated miR-127-3p overexpression exerted tumor-suppressive effects in OVCAR-3 and Caov-3 cells by reducing in vitro proliferation and invasion, increasing bufalin sensitivity, and inhibiting in vivo tumor growth. miR‑127-3p directly regulated the BAG5 gene in EOC. 27571744 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 Biomarker phenotype BEFREE In addition, microarray analysis revealed that miR-127-3p regulated a number of migration and invasion-related genes. 24604520 2014