MIR137, microRNA 137, 406928

N. diseases: 171; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE In this commentary, we discuss the known functions of miRNAs in cancer and stem cells, their therapeutic potential and how the findings of Silber et al provide insight into the role of miR-124/miR-137 dysregulation in glioblastomas. 18577221 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 AlteredExpression disease BEFREE Expression of microRNA-137 was increased 3- to 12-fold in glioblastoma multiforme cell lines U87 and U251 following inhibition of DNA methylation with 5-aza-2'-deoxycytidine (5-aza-dC). 18577219 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 Biomarker disease BEFREE In this commentary, we discuss the known functions of miRNAs in cancer and stem cells, their therapeutic potential and how the findings of Silber et al provide insight into the role of miR-124/miR-137 dysregulation in glioblastomas. 18577221 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE Here, we show that expression of mature miR-137 in melanoma cell lines down-regulates MITF expression. 18316599 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Taken together, our results clearly show that miR-137 and miR-193a are tumor suppressor miRNAs epigenetically silenced during oral carcinogenesis. 18381414 2008
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE Taken together, our results clearly show that miR-137 and miR-193a are tumor suppressor miRNAs epigenetically silenced during oral carcinogenesis. 18381414 2008
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE In this commentary, we discuss the known functions of miRNAs in cancer and stem cells, their therapeutic potential and how the findings of Silber et al provide insight into the role of miR-124/miR-137 dysregulation in glioblastomas. 18577221 2008
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.100 AlteredExpression disease BEFREE Expression of microRNA-137 was increased 3- to 12-fold in glioblastoma multiforme cell lines U87 and U251 following inhibition of DNA methylation with 5-aza-2'-deoxycytidine (5-aza-dC). 18577219 2008
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma 		0.030 PosttranslationalModification disease BEFREE Transfection of microRNA-124 or microRNA-137 also induced G1 cell cycle arrest in U251 and SF6969 glioblastoma multiforme cells, which was associated with decreased expression of cyclin-dependent kinase 6 and phosphorylated retinoblastoma (pSer 807/811) proteins. 18577219 2008
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.020 Biomarker group BEFREE miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. 18577219 2008
CUI: C0028945
Disease: oligodendroglioma
oligodendroglioma 		0.020 Biomarker disease BEFREE Transfection of microRNA-124 or microRNA-137 induced morphological changes and marker expressions consistent with neuronal differentiation in mouse neural stem cells, mouse oligodendroglioma-derived stem cells derived from S100 beta-v-erbB tumors and cluster of differentiation 133+ human glioblastoma multiforme-derived stem cells (SF6969). 18577219 2008
CUI: C0034885
Disease: Rectal Neoplasms
Rectal Neoplasms 		0.020 AlteredExpression group LHGDN Micro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer. 18695884 2008
CUI: C0279070
Disease: Adult Oligodendroglioma
Adult Oligodendroglioma 		0.020 Biomarker disease BEFREE Transfection of microRNA-124 or microRNA-137 induced morphological changes and marker expressions consistent with neuronal differentiation in mouse neural stem cells, mouse oligodendroglioma-derived stem cells derived from S100 beta-v-erbB tumors and cluster of differentiation 133+ human glioblastoma multiforme-derived stem cells (SF6969). 18577219 2008
CUI: C0280475
Disease: Childhood Oligodendroglioma
Childhood Oligodendroglioma 		0.020 Biomarker disease BEFREE Transfection of microRNA-124 or microRNA-137 induced morphological changes and marker expressions consistent with neuronal differentiation in mouse neural stem cells, mouse oligodendroglioma-derived stem cells derived from S100 beta-v-erbB tumors and cluster of differentiation 133+ human glioblastoma multiforme-derived stem cells (SF6969). 18577219 2008
CUI: C0751396
Disease: Well Differentiated Oligodendroglioma
Well Differentiated Oligodendroglioma 		0.020 Biomarker disease BEFREE Transfection of microRNA-124 or microRNA-137 induced morphological changes and marker expressions consistent with neuronal differentiation in mouse neural stem cells, mouse oligodendroglioma-derived stem cells derived from S100 beta-v-erbB tumors and cluster of differentiation 133+ human glioblastoma multiforme-derived stem cells (SF6969). 18577219 2008
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.010 AlteredExpression disease BEFREE Micro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer. 18695884 2008
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.100 Biomarker disease BEFREE Further, methylation of the hsa-miR-9-1, hsa-miR-129-2 and hsa-miR-137 CpG islands were frequently observed in CRC cell lines and in primary CRC tumors, but not in normal colonic mucosa. 19521961 2009
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. 20643829 2010
CUI: C0236736
Disease: Cocaine-Related Disorders
Cocaine-Related Disorders 		0.300 Biomarker group CTD_human Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. 20643829 2010
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.300 Biomarker disease CTD_human Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. 20643829 2010
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.100 PosttranslationalModification disease BEFREE Methylation of the miR-137 CpG island was a cancer-specific event and was frequently observed in CRC cell lines (100%), adenomas (82.3%), and CRC (81.4%), but not in N-C (14.4%; P < 0.0001 for CRC) and N-N (4.7%; P < 0.0001 for CRC). 20682795 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Our data indicate that miR-137 acts as a tumor suppressor in the colon and is frequently silenced by promoter hypermethylation. 20682795 2010
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 AlteredExpression phenotype BEFREE Herein, we describe the epigenetic regulation of miR-137 and its contribution to colorectal carcinogenesis. 20682795 2010
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.040 Biomarker disease BEFREE Promoter methylation of miR-137 appears to be a relatively frequently detected event in oral rinse of SCCHN patients and may have future utility as a biomarker in DNA methylation panels. 20197299 2010
CUI: C0001430
Disease: Adenoma
Adenoma 		0.030 PosttranslationalModification group BEFREE Methylation of the miR-137 CpG island was a cancer-specific event and was frequently observed in CRC cell lines (100%), adenomas (82.3%), and CRC (81.4%), but not in N-C (14.4%; P < 0.0001 for CRC) and N-N (4.7%; P < 0.0001 for CRC). 20682795 2010