|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of miR-142-3p significantly inhibited cell proliferation and cell cycle progression in vitro, and suppressed tumor growth in a mouse model.
|
26183850 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, miR-142-3p functions tumor suppressive effects in cell proliferation and invasion in cervical cancer cells, suggesting a potential therapeutic approach for cervical cancer.
|
25976503 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MicroRNA (miR)‑142‑5p is a member of the miR‑142 family, which have been shown to be associated with tumors, stem cells and disorders of the immune system.
|
25586666 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MiR-142-3p was demonstrated to reduce the proliferation rate of WRO and FTC133 cells, supporting its tumor suppressor role in thyroid cancerogenesis.
|
25238203 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On the contrary, silencing of endogenous miR142-3p dramatically increased the tumor-initiating and stem-like cell capacities in ATRT cells or ATRT-CD133(-) cells and further promoted the mesenchymal transitional and radioresistant properties of ATRT cells.
|
24816458 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Functional studies with miR-142-3p stably transduced in HCC cells demonstrated a diminished ability to self-renew, initiate tumor growth, invade, migrate, induce angiogenesis and resist chemotherapy.
|
25015418 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of endogenous miR-142 effectively suppressed organoid formation by BCSCs and slowed tumor growth initiated by human BCSCs in vivo.
|
25406066 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The xenograft mouse model also revealed the suppressive effect of miR-142-3p on tumor growth.
|
24803022 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Reduction of miR-142-3p corresponds to poor differentiation and bigger tumor size in colon cancers.
|
23619912 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The differentiation between pulmonary adenocarcinoma patients with low and high risk for recurrence was improved by accounting for both miR-142-3p levels and tumour stage (p=0.007; AUC=0.78).
|
23410826 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
More importantly, stratified analysis indicated that high miR-142-3p expression was correlated to a poor prognosis within good-prognosis groups comprised of ESCC patients with small tumor size, negative lymph node metastasis, or early stage (all P < 0.05).
|
21882196 |
2012 |