Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results showed that there exists a close correlation between miR-146a and the radiotherapy effect on HCC progression through regulation of RPA3 and the DNA repair pathway.
|
30462539 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a previous study, we identified miR146a as an exosomal factor that promotes M2-polarization and suppresses the anti-HCC function of T-cells.
|
31181729 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, the function of miR-146a in the pathogenesis of HCC is also discussed.
|
31612014 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, identification of a role of the exosomal SALL4/miR-146a-5p regulatory axis in M2-polarization as well as HCC progression provides potential targets for therapeutic and diagnostic applications in liver cancer.
|
31143524 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, a seven-miRNA expression signature (miR-127-5p, miR-146a, miR-152, miR-193a-3p, miR-331-5p, miR-500a*, and miR-550a*) was identified as a predictor for HCC PFS (p < .0001; HR = 2.608).
|
31210353 |
2019 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the subgroup analysis for cancer types, miR-146a rs2910164 polymorphism was associated with the susceptibility of lung cancer (CC vs. GG: OR 1.275, 95% CI 1.117-1.455 (P = 0.000); CC + CG vs. GG: OR 1.166, 95% CI 1.052-1.293 (P = 0.003); CC vs. CG + GG: OR 1.239, 95% CI 1.116-1.375 (P = 0.000); C vs. G OR 1.151, 95% CI 1.080-1.227 (P = 0.000)) and nasopharyngeal carcinoma (CC vs. GG: OR 1.713, 95% CI 1.183-2.479 (P = 0.004); CC vs. CG + GG: OR 1.672, 95% CI 1.330-2.103 (P = 0.000); C vs. G: OR 1.400, 95% CI 1.181-1.659 (P = 0.000)), but it was not associated with hepatocellular carcinoma and gastric cancer.
|
29127520 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The down-regulation of miR-146a-5p in HCC has been validated with the most complete data possible.
|
28396836 |
2017 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cellular jun proto-oncogene mRNA, LAMP2 mRNA, miR-16 and miR-146a level were investigated in the serum and tissue of patients with hepatocellular carcinoma (HCC), chronic hepatitis C and healthy volunteers by quantitative real-time PCR.
|
28770611 |
2017 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The analysis for miR-146a rs2910164 polymorphisms by racial decent found the same association between miR-146a rs2910164 polymorphism and susceptibility to HCC in Asians, but no significance risk association was observed in Caucasians.
|
28188097 |
2017 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis supports that the miR-146a rs2910164 polymorphism contributes to the risk of HCC from currently available evidence.
|
27886162 |
2017 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Meta-analysis showed that miR-146a was associated with HCC risk under the heterozygote model (OR=1.10, 95%CI=1.03-1.17, P=0.007), whereas no association was found in Caucasian using all genetic models.
|
28499985 |
2017 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, miR-146a C>G (rs2910164) can increase HBV-related HCC risk while miR-196a-2 C>T (rs11614913) may decrease the risk of HBV- and HCV-related HCC, especially in the Chinese population.
|
28148887 |
2017 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genome-wide microarray and computational analyses indicated that miR-146a-5p overexpression modulates pathways that are related to liver disease and HCC development.
|
27147737 |
2016 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between microRNA-196A2 and microRNA-146A polymorphisms and progression to cirrhosis and hepatocellular carcinoma in patients with viral hepatitis B.
|
26529280 |
2016 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CG and GG miR-146a genotypes significantly elevated the risk of hepatocellular carcinoma compared with the CC genotype, with adjusted ORs (95%CI) of 3.05 (1.07-8.70) and 4.96 (1.64-14.97), respectively.
|
27706712 |
2016 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This further insight into understanding the mechanism responsible for tumor-induced immune suppression highlights the potential application of miR-146a as a novel immunotherapeutic target for HCC.
|
25607648 |
2015 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multivariate regression analyses showed that subjects carrying the miR-146a G allele and miR-499 G allele were associated with a non-significant increased risk of HCC compared with subjects with the homozygous allele, with adjusted odds ratios (95% confidence interval) of 1.38 (0.97-1.84) and 1.40 (0.99-2.08), respectively.
|
25867338 |
2015 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Predictive role of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) in the development of hepatocellular carcinoma.
|
26823863 |
2015 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The restoration of miR-146a dramatically suppressed HCC cell invasion and metastasis by repressing VEGF expression through upregulating APC, which inhibits β-catenin accumulation in nucleus, and downregulating NF-κB p65 by targeting HAb18G.
|
25608619 |
2015 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
With respect to miR-146a rs2910164 polymorphism, statistical significant increased HCC risk was found when all studies were pooled into the meta-analysis (GG+CG vs CC: OR = 1.097, 95% CI 1.005-1.197, P = 0.037).
|
25546664 |
2014 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subjects with miR-146a GG and G allele had an increased risk of HCC compared with the homozygote CC genotype.
|
24816919 |
2014 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, miR-146a plays a vital role in the cell growth and apoptosis of HCC cells and inducing miR-146a level might be a critical targeted molecular therapy strategy for HCC.
|
24895573 |
2014 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of miR-146a is related to HCC carcinogenesis and deterioration of HCC.
|
24172202 |
2014 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Results show that both allele frequency and genotype distributions of miR-146a rs2910164 polymorphism are significantly associated with susceptibility to HCC (G versus C: OR = 1.153, 95% CI 1.083-1.228, P < 0.001; GC versus CC: OR = 1.165, 95% CI 1.054-1.286, P = 0.003; GG versus CC: OR = 1.361, 95% CI 1.192-1.553, P < 0.001; GG/GC versus CC: OR = 1.213, 95% CI 1.104-1.333, P < 0.001; GG versus GC/CC: OR = 1.210, 95% CI 1.080-1.356, P < 0.001).
|
25108400 |
2014 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The two common polymorphisms miR-146a G>C and miR-196a2 C>T were associated with decreased HCC susceptibility, especially in Asian population.
|
24860819 |
2014 |