|
Alcoholic Liver Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
MicroRNA-200a induces apoptosis by targeting ZEB2 in alcoholic liver disease.
|
29251244 |
2018 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our present study provides a new insight that the modulation of miR-200a-5p and its target gene might block necroptosis in the heart, revealing a novel myocardial necrosis regulation model in heart disease.
|
29248830 |
2018 |
|
Ovarian Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-200a promotes cell invasion and migration of ovarian carcinoma by targeting PTEN.
|
30024595 |
2018 |
|
Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that 6 mRNAs (HSPA4L, PANK3, YOD1, CTNNBIP1, EVI2B, ITGAL), 3 miRNAs (hsa-miR-125a-3p, hsa-miR-200a, hsa-miR-142-3p) and 3 lncRNAs (MALAT1, TUG1, FGD5-AS1) might be involved in the lncRNA-associated ceRNA network of periodontitis.
|
29516510 |
2018 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
The neuroprotective potential of Tβ4 has been associated with increased miR-200a and miR-200b within the brain following stroke.
|
29873258 |
2018 |
|
Thyroid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
A potential biomarker hsa-miR-200a-5p distinguishing between benign thyroid tumors with papillary hyperplasia and papillary thyroid carcinoma.
|
30005075 |
2018 |
|
Alcohol abuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
Functional enrichment of the miR-183C and miR-200a/b family target genes, revealed neuroinflammatory pathways networks involved in TLR4 signaling and alcohol abuse.
|
30374194 |
2018 |
|
Benign neoplasm of thyroid gland
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To address this, hsa-miR-200a-5p, a miRNA, was selected and detected in PTC patients by in situ hybrization with benign thyroid tumor with papillary hyperplasia as a control, and the differential expression of hsa-miR-200a-5p between fresh PTC tissues and control was detected by qRT-PCR.
|
30005075 |
2018 |
|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our study demonstrated that miR-200a regulates the apoptosis of hepatocyte in ALD by directly target ZEB2, both of which could serve as new therapeutic targets for ALD.
|
29251244 |
2018 |
|
Lichen Planus, Oral
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, we conclude that lack of significant alterations in miR-31 and miR-200a levels in saliva of OLP patients may be indicative for absence of malignant transformation.
|
29480379 |
2018 |
|
Erectile dysfunction
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA MIAT promoted BM-MSCs differentiation into ECs and restored ED via miR-200a.
|
29486902 |
2018 |
|
Leukocyte adhesion deficiency type 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of miR-200a repressed the cell proliferation and blocked the increase of LAD cell proliferation caused by GOLM1 overexpression.
|
29710483 |
2018 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Previous studies have shown that miR-200a is markedly deregulated in various neurodegenerative disorders including Alzheimer's disease (AD), Multiple Sclerosis (MS) and PD.
|
29936262 |
2018 |
|
Progressive Neoplastic Disease
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The serum levels of miR-200a before chemotherapy were compared between patients who were responsive to chemotherapy [complete response (CR) and partial response (PR)] and patients who were not responsive to chemotherapy [stable disease (SD) and progressive disease (PD)].
|
29556307 |
2018 |
|
Diarrhoea predominant irritable bowel syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study suggests that miR-200a could induce visceral hyperalgesia by targeting the downregulation of CNR1 and SERT, aggravating or leading to the development and progression of IBS-D. MiR-200a may be a regulator of visceral hypersensitivity, which provides potential targets for the treatment of IBS-D.
|
30347941 |
2018 |
|
Renal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Decreased miR-200a-3p is a key regulator of renal carcinoma growth and migration by directly targeting CBL.
|
30171729 |
2018 |
|
Myocardial necrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our present study provides a new insight that the modulation of miR-200a-5p and its target gene might block necroptosis in the heart, revealing a novel myocardial necrosis regulation model in heart disease.
|
29248830 |
2018 |
|
Mucosal atrophy
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of the present study was to investigate an association of genetic polymorphism (rs7521584) located in miR‑200a‑200b‑429 cluster, which has tumor suppressor and pro‑inflammatory function, with the development of gastric mucosal atrophy and metaplasia as a pre‑malignant condition.
|
29956763 |
2018 |
|
Idiopathic pulmonary arterial hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study demonstrated the role of H19-miR-675-3p-IGF1R- and H19-miR-200a-PDCD4-signaling pathways in the melatonin treatment of PAH.
|
30240970 |
2018 |
|
Progressive cGVHD
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The serum levels of miR-200a before chemotherapy were compared between patients who were responsive to chemotherapy [complete response (CR) and partial response (PR)] and patients who were not responsive to chemotherapy [stable disease (SD) and progressive disease (PD)].
|
29556307 |
2018 |
|
Hepatitis B
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of miR-200a-3p induced by hepatitis B Virus X (HBx) Protein promotes cell proliferation and invasion in HBV-infection-associated hepatocarcinoma.
|
29103765 |
2017 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, we identified miR200a-3p, which is highly expressed in Hdo cells and stem cells but poorly expressed in differentiated cells and mature hepatocytes, as a novel negative regulator of HCV replication.
|
28903311 |
2017 |
|
Immune System Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our results provided a strong evidence that up-regulation of microRNA-200a in CD4+ T cells may induce immune dysfunction through Th17/Treg cells and relevant cytokines in PV patients.
|
28738533 |
2017 |
|
Lipid Metabolism Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Our study demonstrated that SIRT1 pathway mediated the effects of beraprost sodium on attenuation of hepatic lipid disorders induced by fructose and revealed the primary role of miR-200a in the regulation of hepatic SIRT1 by beraprost sodium.
|
28732575 |
2017 |
|
Psoriasis vulgaris
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MiR-200a expression in CD4+ T cells correlates with the expression of Th17/Treg cells and relevant cytokines in psoriasis vulgaris: A case control study.
|
28738533 |
2017 |