Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR-21.
|
23888942 |
2014 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we selected two miRNAs, hsa-miR-21 and hsa-miR-29, as the targets to assess their diagnostic and prognostic value for GC.
|
26509997 |
2015 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-21 could serve as an efficient diagnostic marker for gastric cancer, but does not affect the clinical prognosis of gastric cancer patients.
|
18507035 |
2008 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, the proposed strategy could be satisfactory for rapid, ultrasensitive and efficient detection of microRNA-21, and held great potentials in clinic diagnosis of gastric cancer.
|
28919434 |
2017 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study elucidated whether Helicobacter pylori-infected first-degree relatives of patients with gastric cancer (GCF) are susceptible to have SPEM and correlated with miR-21, 155, and 223 expressions.
|
30990573 |
2019 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Patients with gastric cancer display a significantly higher level of miR-21 in peripheral blood than those from controls.
|
22430134 |
2012 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings contribute to our understanding of the functions of miR-21 and exosomes as a carrier for therapy of gastric cancer.
|
26028073 |
2015 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest circulating miR-21 (both in serum and in PBMCs) can serve as a good biomarker for GC and could be used in diagnosis of early (stage I) and late GC (stage IV).
|
26063956 |
2015 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of miR-21 decreased the sensitivity of GC cells to trastuzumab, while suppression of miR-21 expression restored the resistance of GC cells to trastuzumab.
|
24154840 |
2014 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that exosomal transfer of tumor-associated macrophages derived miR-21 confer DDP resistance in gastric cancer, and targeting exosome communication may be a promising new therapeutic strategy for gastric cancer patients.
|
28407783 |
2017 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Enhanced antiproliferative activity of antibody-functionalized polymeric nanoparticles for targeted delivery of anti-miR-21 to HER2 positive gastric cancer.
|
28978026 |
2017 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study is a continuation of earlier findings involving poly(ε-caprolactone) (PCL)-poly (ethylene glycol) (PEG) nanoparticles (PEG-PCL NPs), which were coated with trastuzumab to target GC with HER2 receptor over-expression using anti-miRNA-21 (AMO-21) and 5-Fu.
|
29241186 |
2017 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bmi-1 positively regulates stem cell-like properties of gastric cancer and upregulates miR-21 and miR-34a.
|
27644439 |
2016 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evaluation of circulating miR-21 and miR-222 as diagnostic biomarkers for gastric cancer.
|
30880765 |
2019 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miRNA-21 promotes gastric cancer growth by adjusting prostaglandin E2.
|
29687845 |
2018 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-21: Mechanisms of Oncogenesis and its Application in Diagnosis and Prognosis of Gastric Cancer.
|
26265521 |
2015 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Remarkably, miR-21 was also significantly overexpressed in H. pylori-infected gastric mucosa, implying that overexpression of miR-21 in gastric cancer may be due in part to H. pylori infection.
|
18794849 |
2008 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpressed miR-21 was observed in GC tissues and cell lines.
|
29710493 |
2018 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results suggested plasma miR-21 could be a novel potential biomarker for GC prognosis and evaluation of surgery outcomes, especially in patients without a family history.
|
24460332 |
2013 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the relationship between MEG3 and miR‑21 in regards to the cell mobility of gastric cancer.
|
29749532 |
2018 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our findings enlarged our knowledge in the roles of miR-21 in the progression of gastric cancer.
|
29101039 |
2018 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ex-miR-21 levels were significantly higher and ex-miR-92a levels were significantly lower in samples from patients with GC compared with healthy controls.
|
31611956 |
2019 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Literature database including PubMed, Embase, the Cochrane Library, Web of Science, Ovid, SciVerse, Science Direct, Scopus, BioMed Central, Biosis previews,Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP), and Wan Fang DATA were searched for publications concerning the diagnostic value of miR-21 for GC without language restriction.
|
24023850 |
2013 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-21 Inhibitors Modulate Biological Functions of Gastric Cancer Cells via PTEN/PI3K/mTOR Pathway.
|
29185784 |
2018 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differential expression of miR-21, miR-320c, and miR-1225-5p was validated in the PLF of serosa-invasive and non-invasive GC by qRT-PCR and miR-21 and miR-1225-5p were confirmed to be associated with serosal invasion in GC.
|
26208314 |
2015 |