|
Obesity
|
0.380 |
Biomarker
|
disease |
BEFREE |
Epigenetic origin of the link between obesity and breast cancer (BC) is investigated in a cohort of Tunisian patients, focusing on polymorphism at germline level (miR-146a) and on expression in mammary tumors (miR-21, miR-146a, and miR-34a), according to body mass index (BMI) and clinico-pathologic features.
|
30303554 |
2019 |
|
Obesity
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
A reduced level of miR-21 might associate with obesity and its related metabolic traits such as hyperinsulinaemia.
|
29113498 |
2018 |
|
Obesity
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Failure of isoflurane cardiac preconditioning in obese type 2 diabetic db/db mice is associated with aberrant regulation of microRNA-21, endothelial nitric-oxide synthase, and mitochondrial respiratory complex I.
|
29040168 |
2018 |
|
Obesity
|
0.380 |
Biomarker
|
disease |
BEFREE |
Ginger Extract Ameliorates Obesity and Inflammation via Regulating MicroRNA-21/132 Expression and AMPK Activation in White Adipose Tissue.
|
30360535 |
2018 |
|
Obesity
|
0.380 |
Biomarker
|
disease |
BEFREE |
Therefore, miR‑21 may be a key regulatory factor of obesity and obesity‑associated insulin resistance, and represents a potential therapeutic target for the treatment of these disorders.
|
28627656 |
2017 |
|
Obesity
|
0.380 |
Biomarker
|
disease |
CTD_human |
Obese mouse ovaries had decreased Irs1, Foxo3a, Cyp2e1, MiR-103, and MiR-21 but increased Kitlg, Akt1, and miR-184 levels relative to lean littermates.
|
23954404 |
2013 |
|
Obesity
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
However, there was a significant interaction between obesity and the group of subjects in the expression of miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 consisting of obesity reducing the expression of these miRNAs in control woman and men, but tending to increase their expression in women with PCOS.
|
24037889 |
2013 |
|
Obesity
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Multivariate analysis showed that the expression of miR-21 was an independent risk factor for recurrence in obese (HR=6.15, 95% CI=1.04-36.48, P=0.045), but not in non-obese (HR=1.28, 95% CI=0.30-5.49, P=0.74) cases.
|
23353719 |
2013 |
|
Obesity
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
These findings provide the evidence of the correlation between miR-21 level and adipocyte number in the white adipose tissue of HFD-induced obese mice, which provides new insights into the mechanisms of obesity.
|
21381024 |
2012 |