Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
MiR-21 affects the sensitivity of esophageal cancer to cisplatin through targeting PDCD4.
|
30840273 |
2019 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Dysregulation of miR-203-3p and miR-21-5p has been identified in esophageal cancer (EC).
|
30134284 |
2019 |
Malignant neoplasm of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition to known somatic miR-142 mutations in hematologic cancers, we describe novel somatic miR-21 mutations in esophageal cancers impacting downstream miRNA targets.
|
30302893 |
2019 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Multiple lines of evidence indicate that the presence, absence, or deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer) are associated with initiation and progression of gastric and esophageal cancers.
|
29923196 |
2018 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
To evaluate the diagnostic potential of a six microRNAs (miRNAs) panel consisting of miR-21, miR-144, miR-107, miR-342, miR-93 and miR-152 for esophageal cancer (EC) detection.
|
29380534 |
2018 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
The expression levels of miR-21, miR-31, miR-93 and miR-375 were different when Zn levels were varied in EC cell lines, but only miR-21 and miR-375 were associated with patient characteristics and prognosis in patients with EC from an area of China with a high incidence of EC.
|
27885434 |
2017 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, exosome-shuttling miR-21 may become a potential biomarker for prognosis among esophageal cancer patients.
|
27035745 |
2016 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
We selected 5 miRNAs (miRNA-21, -143, -145, -196a and let-7) based on the available literature, and described their potential role in regulating pathways that are deregulated in esophageal cancer.
|
26755856 |
2016 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer.
|
26481465 |
2015 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results support a prognostic role for miR-21 in EC.
|
26125864 |
2015 |
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Fluorescence quantitative polymerase chain reaction analysis was used to detect the expression of miR-21 in human esophageal tissues, adjacent tissues, and an esophageal cancer cell line (TE-13).
|
26345812 |
2015 |
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of miR-21 and down-regulation of miR-375 can predict unfavourable prognosis in esophageal cancer.
|
24680681 |
2014 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Differentially expressed miRNA analysis selected four miRNAs associated with EAC and ESCC, among which hsa-miR-21 and hsa-miR-202 were shared by both diseases. hsa-miR-202 was reported for the first time to be associated with esophageal cancer in the present study.
|
25098614 |
2014 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inhibition of miR-21 may form a novel therapeutic strategy to increase the radiosensitivity of esophageal cancer.
|
22958183 |
2014 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nicotine upregulates microRNA-21 and promotes TGF-β-dependent epithelial-mesenchymal transition of esophageal cancer cells.
|
24756761 |
2014 |
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our findings suggest that miR-203 may act as novel tumor suppressor in esophageal cancer through down-regulating the expression of Ran and miR-21.
|
24001611 |
2014 |
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A co-culture system of normal fibroblasts and esophageal cancer cells was used to determine the effects of fibroblasts on miR-21 expression levels, and on SCC cell migration and invasion.
|
24039846 |
2013 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Saliva supernatant miR-21 may be a novel biomarker for EC.
|
23464420 |
2012 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer.
|
22689922 |
2012 |
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
CTD_human |
Using 98 formalin-fixed, paraffin-embedded samples obtained from patients with esophageal cancer who had received preoperative chemotherapy followed by surgery, we measured expression levels of several miRNAs that are considered to be involved in the regulation of stem cell function (e.g., let-7a, let-7g, miR-21, miR-134, miR-145, miR-155, miR-200c, miR-203, and miR-296) by real-time reverse transcriptase PCR.
|
21248297 |
2011 |
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MiR-21 expressions were investigated in esophageal cancer cell line Eca109, and 18 pairs of Kazakh's ESCC and adjacent normal tissues by real-time quantitative PCR (qRT-PCR).
|
21104017 |
2011 |