|
Progression of prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, circFOXO3 acts as a miR-29a-3p sponge to exhibit oncogenic activity that affects the cell cycle and cell apoptosis in PCa through transcriptional up-regulation of SLC25A15.
|
31733095 |
2020 |
|
AIDS related complex
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, the interaction among lncRNA H19, miR-29a and TDG is involved in early ARC. lncRNA H19 could be a useful marker of early ARC and oxidative damage repair pathway of lncRNA H19/miR-29a/TDG may be a promising target for the treatment of ARC.
|
31282110 |
2019 |
|
Alopecia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, these synergistic targets reveal miR-29a/b1 as a high-fidelity antagonist of HFSC lineage progression and a potential therapeutic target for hair loss.
|
31747615 |
2019 |
|
Arteriosclerosis Obliterans
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study showed that miR-29a is downregulated in the arterial wall of ASO patients, as well as in the PDGF-BB-stimulated HASMCs.
|
31614351 |
2019 |
|
Bursitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, miR-29a loss is correlated with subacromial bursa inflammation and fibrosis in rotator cuff tear with shoulder stiffness. miR-29a repressed subacromial bursa fibrosis through directly targeting COL3A1 mRNA, improving rotator cuff integrity and shoulder function.
|
31731750 |
2019 |
|
Charcot-Marie-Tooth Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Downregulation of the human peripheral myelin protein 22 gene by miR-29a in cellular models of Charcot-Marie-Tooth disease.
|
31455873 |
2019 |
|
Ependymoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The most specific were miR-10a and miR-29a low expression in LGG non-responders, miR-135a and miR-146b over-expression in ependymoma non-responders, and miR-135b overexpression in medulloblastoma non-responders.
|
29658967 |
2019 |
|
Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The most specific were miR-10a and miR-29a low expression in LGG non-responders, miR-135a and miR-146b over-expression in ependymoma non-responders, and miR-135b overexpression in medulloblastoma non-responders.
|
29658967 |
2019 |
|
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that miR-29a is involved in GC proliferation and steroidogenesis, providing insights into PCOS pathogenesis.
|
31421163 |
2019 |
|
Bicuspid aortic valve
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, we also found that only miR-29A is significantly downregulated in BAVs.
|
31501876 |
2019 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic curve analysis showed that miR-29a-3p could be used to screen AMI patients from healthy controls.
|
31410131 |
2019 |
|
Hypertrophy of kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, using gain-of-function transgenic mice, we demonstrated that miR-29a acts as a negative regulator of CB1R, blocks the expressions of these proinflammatory and profibrogenic mediators, and attenuates renal hypertrophy.
|
30642005 |
2019 |
|
Cicatrix, Hypertrophic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immoderate proliferation and deposition of collagen generally result in hypertrophic scars and even keloids. microRNA-29 (miR-29) has been proved as a crucial regulator in these pathological processes.
|
31081145 |
2019 |
|
Flavivirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
ZIKV-modulated miRNAs including miR-155, miR-203, miR-29a, and miR-124-3p are known to play critical role in flavivirus infection, anti-viral immunity and brain injury.
|
30781519 |
2019 |
|
Shoulder stiff
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, miR-29a loss is correlated with subacromial bursa inflammation and fibrosis in rotator cuff tear with shoulder stiffness. miR-29a repressed subacromial bursa fibrosis through directly targeting COL3A1 mRNA, improving rotator cuff integrity and shoulder function.
|
31731750 |
2019 |
|
Rotator cuff syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, miR-29a loss is correlated with subacromial bursa inflammation and fibrosis in rotator cuff tear with shoulder stiffness. miR-29a repressed subacromial bursa fibrosis through directly targeting COL3A1 mRNA, improving rotator cuff integrity and shoulder function.
|
31731750 |
2019 |
|
Childhood Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The most specific were miR-10a and miR-29a low expression in LGG non-responders, miR-135a and miR-146b over-expression in ependymoma non-responders, and miR-135b overexpression in medulloblastoma non-responders.
|
29658967 |
2019 |
|
Adult Ependymoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The most specific were miR-10a and miR-29a low expression in LGG non-responders, miR-135a and miR-146b over-expression in ependymoma non-responders, and miR-135b overexpression in medulloblastoma non-responders.
|
29658967 |
2019 |
|
Adult Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The most specific were miR-10a and miR-29a low expression in LGG non-responders, miR-135a and miR-146b over-expression in ependymoma non-responders, and miR-135b overexpression in medulloblastoma non-responders.
|
29658967 |
2019 |
|
Superficial ulcer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we showed that transgenic mice overexpressing an miR-29a precursor driven by phosphoglycerate kinase exhibited a minor response to glucocorticoid-mediated bone mineral density loss, cortical bone porosity and overproduction of serum resorption markers C-teleopeptide of type I collagen and tartrate-resistant acid phosphatase 5b levels. miR-29a overexpression compromised trabecular bone erosion and excessive osteoclast number histopathology in glucocorticoid-treated skeletal tissue.
|
31627291 |
2019 |
|
Osteoglophonic dwarfism
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we aimed to determine whether miR‑29a played a protective role in oxygen glucose deprivation (OGD) injury via regulation of the water channel protein aquaporin 4 (AQP4).
|
30628716 |
2019 |
|
Acute Chest Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two miRNAs (hsa-miR-29 and hsa-miR-1) and three TFs (NFIC, NFKB1 and RELA) were critical genes involved in pathological process of ACS.
|
31550669 |
2019 |
|
Newly Diagnosed Childhood Ependymoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The most specific were miR-10a and miR-29a low expression in LGG non-responders, miR-135a and miR-146b over-expression in ependymoma non-responders, and miR-135b overexpression in medulloblastoma non-responders.
|
29658967 |
2019 |
|
Oestrogen deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also highlight that increasing miR-29a function in osteoblasts is beneficial for bone anabolism to fend off estrogen deficiency-induced excessive osteoclastic resorption and osteoporosis.
|
31543513 |
2019 |
|
Endothelial dysfunction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, the effects of miR-29a-3p on endothelial dysfunction were assessed in C57BL/6 mice injected with TNFα and/or a miR-29a-3p agomir.
|
31760375 |
2019 |