EPCAM, epithelial cell adhesion molecule, 4072

N. diseases: 328; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042164
Disease: Uveitis
Uveitis
0.010 Biomarker disease BEFREE Efficacy trended better with EGP-437 among patients with more severe baseline uveitis (AC cell count >25). 31726034 2020
Congenital contractural arachnodactyly
0.010 AlteredExpression disease BEFREE CD133 or EpCAM expression in the CCA component was associated with poor prognosis in cHCC-CCA. 31661725 2020
CUI: C0545069
Disease: Intermediate cell carcinoma
Intermediate cell carcinoma
0.010 Biomarker disease BEFREE For EpCAM, the positive rate in the CCA component (71.4%) and INT component (50.0%) tended to be higher than the HCC component (14.3%) in cHCC-CCA. 31661725 2020
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation
0.010 Biomarker disease BEFREE These were validated offline in their ability to identify the ESA targeted with a study-defined ablation response (AF termination or cycle length [CL] slowing of ≥30 ms). 31552697 2019
CUI: C0016382
Disease: Flushing
Flushing
0.010 Biomarker phenotype BEFREE After covalent attachment of anti-EpCAM (epithelial cell adhesion molecule) antibodies on stainless steel substrates, EV samples derived from a prostate cancer cell line (LnCAP) were flushed into a microfluidic device assembled with this stainless steel substrate for capture. 31292600 2019
CUI: C0018939
Disease: Hematological Disease
Hematological Disease
0.010 Biomarker group BEFREE Thalassemia (Thal) is an inherited blood disorder endemic to the Mediterranean and Middle East (e.g., KSA and UAE). 31141729 2019
CUI: C0019187
Disease: Hepatitis, Alcoholic
Hepatitis, Alcoholic
0.010 Biomarker disease BEFREE EPCAM was predicted to regulate AH progression through the PI3K/Akt/mTOR signaling pathway. 31378124 2019
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.010 Biomarker group BEFREE LGR5 is predominant in peri-septal hepatocytes rather than epithelial cell adhesion molecule (EpCAM) positive ductular reactions in chronic pediatric liver diseases and may represent a transitional HPC phenotype for the hepatocyte lineage. 28276299 2019
CUI: C0024232
Disease: Lymphatic Metastasis
Lymphatic Metastasis
0.010 Biomarker disease BEFREE Prognostic value of biomarkers EpCAM and αB-crystallin associated with lymphatic metastasis in breast cancer by iTRAQ analysis. 31443698 2019
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.010 Biomarker disease BEFREE Immunocytochemical studies on PF cell blocks allow: (a) to distinguish mesothelioma from reactive mesothelial proliferations (e.g. loss of BAP1 nuclear expression, complemented by the demonstration of p16 deletion using fluorescence in situ hybridization, indicate mesothelioma); (b) to separate mesothelioma from adenocarcinoma (e.g. calretinin, CK 5/6, WT-1 and D2-40 are markers of mesothelioma, whereas CEA, EPCAM, TTF-1, napsin A, and claudin 4 are markers of carcinoma); and (c) to reveal tumor origin in pleural metastases of an unknown primary site (e.g. 30354850 2019
CUI: C0032227
Disease: Pleural effusion disorder
Pleural effusion disorder
0.010 Biomarker group BEFREE EpCAM(cl) is a new biomarker of adenocarcinomatous PE with meaningful discriminating properties. 30903651 2019
CUI: C0039730
Disease: Thalassemia
Thalassemia
0.010 Biomarker group BEFREE Thalassemia (Thal) is an inherited blood disorder endemic to the Mediterranean and Middle East (e.g., KSA and UAE). 31141729 2019
Secondary malignant neoplasm of bone
0.010 AlteredExpression disease BEFREE No correlation of EpCAM overexpression with pT stage and lymph node metastasis was observed; however, EpCAM overexpression showed a significant correlation with Gleason score (OR = 0.48, P = 0.012) and bone metastasis (OR = 145.80, P <  0.001). 31324239 2019
CUI: C0238339
Disease: Hereditary pancreatitis
Hereditary pancreatitis
0.010 Biomarker disease BEFREE LGR5 is predominant in peri-septal hepatocytes rather than epithelial cell adhesion molecule (EpCAM) positive ductular reactions in chronic pediatric liver diseases and may represent a transitional HPC phenotype for the hepatocyte lineage. 28276299 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.010 Biomarker disease BEFREE Silencing EPCAM or inhibition of the PI3K/Akt/mTOR signaling pathway inhibited the hepatic fibrosis and HSC proliferation yet induced HSC apoptosis. 31378124 2019
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon
0.010 AlteredExpression disease BEFREE Seven cancerous tissue samples of colon adenocarcinoma and corresponding noncancerous tissue samples were sorted by fluorescence-activated cell sorting using epithelial cell adhesion molecule as a marker for epithelial cells. 30918593 2019
Infection caused by Helicobacter pylori
0.010 GeneticVariation disease BEFREE From the literature review, there seem to be no studies conducted on infection caused by Helicobacter pylori in patients with gastric MALT lymphoma in the KSA region. 31250359 2019
Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
0.010 Biomarker disease BEFREE From the literature review, there seem to be no studies conducted on infection caused by Helicobacter pylori in patients with gastric MALT lymphoma in the KSA region. 31250359 2019
CUI: C1699634
Disease: HER-2 positive breast cancer
HER-2 positive breast cancer
0.010 AlteredExpression disease BEFREE In addition, the expression levels of ALDH1A3, ALDH3B2 and EpCAM were higher in HER‑2‑positive breast cancer compared with in paracancerous tissues and other subtypes of breast cancer, as determined by immunohistochemistry. 31545416 2019
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA
0.010 Biomarker disease BEFREE We aimed to demonstrate the feasibility of non-invasive enumeration and immunophenotyping of EpCAM-positive cells in pleural fluid samples for the diagnosis of a MPE in NSCLC patients. 30642547 2019
Metastatic castration-resistant prostate cancer
0.010 Biomarker disease BEFREE Our results reveal for the first time a remarkable heterogeneity in the expression levels of AR-FL, AR-V7 and AR-567es in EpCAM+ CTCs and paired extracellular vesicles between individual mCRPC patients. 31596277 2019
CUI: C0005411
Disease: Biliary Atresia
Biliary Atresia
0.010 Biomarker disease BEFREE The expression of CK19, Sox9, and EpCAM was significantly increased in BA liver, while DAPT treatment decreased the expression of CK19, Sox9, and EpCAM. 30196281 2018
CUI: C0010606
Disease: Adenoid Cystic Carcinoma
Adenoid Cystic Carcinoma
0.010 AlteredExpression disease BEFREE Expression of EpCAM in adenoid cystic carcinoma. 30389218 2018
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.010 Biomarker disease BEFREE Personalized Anemia Management and Precision Medicine in ESA and Iron Pharmacology in End-Stage Kidney Disease. 30082060 2018
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.010 Biomarker disease BEFREE Progenitor-derived regeneration depicted by K7 and EpCAM immunostaining of hepatocytes in liver biopsies of patients with compensated HCV-related cirrhosis marks a cirrhosis stage more prone to develop complications.(HEPATOLOGY 2018; 68:1534-1548). 29637581 2018