Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
After designing and developing a large number of bsAbs for years, catumaxomab, a full-length bsAb targeting EpCAM and CD3, was approved in 2009 to treat EpCAM-positive carcinomas besides blinatumomab, a bispecific T cell engager antibody targeting CD19 and CD3, which was approved in 2014 to treat relapsed or refractory acute lymphoblastic leukemia.
|
31011631 |
2019 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Because of its expression pattern and molecular function, EpCAM is a valuable target in prognostic and therapeutic approaches for various carcinomas.
|
29700109 |
2018 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Epithelial cell adhesion molecule (EpCAM) is a cancer stem cell (CSC) marker that is expressed in various epithelial carcinomas, including EAC.
|
30116994 |
2018 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Therefore, we developed bispecific PARs that selectively target the human CD3 receptor and human epithelial cell adhesion molecule (EpCAM), which is overexpressed on multiple carcinomas and cancer stem cells.
|
29792808 |
2018 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Epithelial cell adhesion molecule (EpCAM) is known to be highly expressed in a variety of epithelial carcinomas, and it is involved in cell adhesion and proliferation.
|
29305578 |
2018 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
However, current CTC assays, which capture CTCs based on expression of epithelial cell adhesion molecule (EpCAM), fail to capture cells from de-differentiated tumors and carcinomas undergoing loss of the epithelial phenotype during the invasion/metastatic process.
|
29366804 |
2018 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Epithelial cell adhesion molecule EpCAM is expressed in pluripotent embryonic stem cells (ESC) in vitro, but is repressed in differentiated cells, except epithelia and carcinomas.
|
29379062 |
2018 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein identified as a tumor specific antigen due to its frequent overexpression in the majority of epithelial carcinomas and its correlation with prognosis.
|
28347886 |
2017 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The levels of EpCAM in the renal epithelium are upregulated both during regeneration after ischemia/reperfusion injury and in renal-derived carcinomas.
|
28411024 |
2017 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Catumaxomab (CATU) is a trifunctional antibody approved for intraperitoneal (i.p.) treatment of malignant ascites (MA) related to carcinomas expressing the epithelial cell-adhesion molecule (EpCAM).
|
26417039 |
2015 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein overexpressed in human epithelioma but with relatively low expression in normal epithelial tissues.
|
25960617 |
2015 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The expression of EpCAM was high on all carcinomas independent of their anatomical localization.
|
26124342 |
2015 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein, which is frequently and highly expressed on carcinomas, tumor-initiating cells, selected tissue progenitors, and embryonic and adult stem cells.
|
25477371 |
2015 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The epithelial cell adhesion molecule (EpCAM) is overexpressed on most carcinomas.
|
23403823 |
2013 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Taking this rather ubiquitous expression of EpCAM in carcinomas and TICs into account, the question arises how EpCAM can serve as a reliable marker for tumor-initiating cells and what might be the advantage for TICs to express this molecule.
|
22647938 |
2012 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that is expressed in most normal human epithelia and overexpressed in most carcinomas.
|
23264216 |
2012 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The epithelial cell adhesion molecule (EpCAM) is overexpressed on carcinomas, and its downregulation inhibits the oncogenic potential of multiple tumour types.
|
21694727 |
2011 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
EpCAM is a cell-surface glycoprotein that is overexpressed in the majority of epithelial carcinomas.
|
22132731 |
2011 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The GA733 gene family is composed of GA733-1 (TROP2) and GA733-2 (Ep-CAM), whose expression has been examined in various carcinomas and reported to be significantly associated with prognosis.
|
20473768 |
2010 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that is overexpressed in the majority of human epithelial carcinomas, including breast and colorectal carcinomas.
|
19141643 |
2009 |
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Expression of the epithelial cell adhesion molecule EpCAM is upregulated in a variety of carcinomas.
|
19002182 |
2008 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Epithelial cell adhesion molecule EpCAM is strongly over-expressed in a variety of carcinomas where it is involved in signalling events resulting in increased expression of target genes such as c-Myc, cyclins and others, eventually conferring cells an oncogenic phenotype.
|
18508581 |
2008 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The epithelial glycoprotein-2 (EGP-2) promoter is active in a broad variety of carcinomas, the most common type of cancer.
|
17137670 |
2007 |
Carcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas.
|
16316942 |
2005 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The human epithelial cell adhesion molecule (EpCAM) is expressed on normal epithelial cells and is overexpressed in most carcinomas.
|
15634917 |
2005 |