|
Malignant tumor of colon
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Next, the expression levels of EpCAM in five colon cancer cell lines were examined by western blotting and flow cytometry.
|
31322180 |
2019 |
|
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Results in this study indicate that EpCAM<sup>+</sup> CD4<sup>+</sup> T cells may play a role in CC development.
|
31354723 |
2019 |
|
Malignant tumor of colon
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The present study established a CPT‑11-resistant colon cancer cell line, LoVo/CPT‑11 cells, and detected the expression levels of CSC identification markers [cluster of differentiation (CD)44, CD133, epithelial cell adhesion molecule (EpCAM) and CD24] in parental cells and CPT‑11-resistant cells.
|
29956726 |
2018 |
|
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
As a result, the relatively larger (<100 nm) particles precipitated by PEG5k clearly exhibited the greatest amount of epithelial cell adhesion molecule (EpCAM), from both breast cancer (MCF-7) and colon cancer (HCT116) cells, and a larger quantity of microRNA (miRNA) specific to breast cancer cells (miRNA155 for MCF-7) seemed to be contained in the PEG-precipitated particles.
|
27917441 |
2017 |
|
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
EpCAM aptamer-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery.
|
26690044 |
2016 |
|
Malignant tumor of colon
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We identified a Japanese Lynch syndrome patient with colon cancer who evidenced germline deletion of a 4130 bp fragment of EPCAM encompassing exons 8 and 9 (c.859-672_*2170del).
|
26613680 |
2016 |
|
Malignant tumor of colon
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Using data from the Colon Cancer Family Registry, we compared the proportion of childhood cancers (diagnosed before 18 years of age) in the first-, second-, and third-degree relatives of 781 probands with a pathogenic mutation in one of the MMR genes; MLH1 (n = 275), MSH2 (n = 342), MSH6 (n = 99), or PMS2 (n = 55) or in EPCAM (n = 10) (Lynch syndrome families), with that of 5073 probands with MMR-deficient colorectal cancer (non-Lynch syndrome families).
|
25963852 |
2015 |
|
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Together, these findings suggest that EpCAM plays an important role in regulating cancer-initiating abilities in TICs of colon cancer.
|
22989882 |
2012 |
|
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
Relationship between ganglioside expression and anti-cancer effects of the monoclonal antibody against epithelial cell adhesion molecule in colon cancer.
|
22033101 |
2011 |
|
Malignant tumor of colon
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The only significant correlation of Ep-CAM expression with tumour grading was observed in colon cancer where high-level Ep-CAM expression on grade 3 tumours was down to 92.1% (P<0.0001).
|
16404366 |
2006 |
|
Malignant tumor of colon
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Murine lymphocytes transduced with the chimeric receptor based on GA733, but not CO17.1A, released cytokine specifically in response to EGP40-expressing colon cancer cell lines.
|
10770638 |
2000 |
|
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
BEFREE |
As colon cancer predominantly metastasizes to liver, and adenovirus has a high tropism for hepatocytes, we also sought to determine if the EpCAM-targeted adenovirus showed reduced infectivity of human liver cells.
|
10467371 |
1999 |
|
Malignant tumor of colon
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|