Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, mechanisms as mutations in TGF-beta receptor II or Smad2 and 4 genes, frequently observed in other human cancers, have only rarely been observed in hepatocellular carcinomas.
|
11170302 |
2001 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that mutations of the TGFbetaRII, Smad2, and Smad4 genes are rare, and that genetic instability is uncommon in human hepatocellular carcinoma.
|
9863018 |
1999 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Using the HepG2 hepatoma cells, we showed here that expression of Smad2.Q407R, a missense mutation found in human hepatocellular carcinoma, was less effective than expression of wild-type Smad2 in enhancing the ability of TGF-beta to induce transcription from the Mix.2 promoter.
|
12700238 |
2003 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that mutations of the hsMAD2, hBUB1 and hBUB3 genes are very rare in bladder tumors and that hsMAD2 alterations are also infrequent in soft-tissue sarcomas and hepatocellular carcinomas.
|
11400114 |
2001 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes.
|
10490821 |
1999 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
To investigate the involvement of autocrine TGF-beta signal in cell growth, PAI-1 and VEGF production of HCC, we made stable transfectants of human HCC line (HuH-7 cells) to express a mutant Smad2(3S-A), in which serine residues of SSXS motif were changed to alanine.
|
12700666 |
2003 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
And we found that LY2109761 could inhibit cell proliferation by down-regulating the phosphorylation of Smad-2 as well as improved the therapeutic effect of TACE in a VX2 hepatocellular carcinoma model.
|
29416682 |
2018 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
cPLA2α activates PI3K/AKT and inhibits Smad2/3 during epithelial-mesenchymal transition of hepatocellular carcinoma cells.
|
28649002 |
2017 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
FOXP3 Is a HCC suppressor gene and Acts through regulating the TGF-β/Smad2/3 signaling pathway.
|
28903735 |
2017 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Consistent with our in vitro data, we demonstrate SCF overexpression and its correlation to SMAD2 and STAT3 activation in human HCC tumors, advanced tumor-node-metastasis stages, and shorter survival.
|
27292026 |
2016 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
RGD |
The expressions of Smad4 and phosphorylated Smad2 in the HCC tissue was significantly lower than those in normal liver tissue.
|
18971187 |
2008 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
A shift in Smad2/3 phosphorylation from the carboxy terminus to linker sites is a key event determining biological function of TGF-β in colorectal and hepatocellular carcinoma.
|
22539990 |
2012 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, JR inhibits liver cancer cells migration and invasion through epithelial mesenchymal transition (EMT) inhibition via Smad2/3 dependent and independent pathways, suggesting it is an effective therapeutic strategy against HCC metastasis.
|
30174709 |
2018 |
Liver carcinoma
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
TGF-β1-induced phosphorylation of Smad2 and Akt was enhanced in RIG-I-deficient HCC spheres, knockdown of AKT gene expression abolishing the augmentation of TGF-β1-induced Smad2 phosphorylation.
|
31088527 |
2019 |
Liver carcinoma
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
Further studies demonstrated that MUC1-mediated JNK activation not only enhances the phosphorylation of Smad2 C-terminal at Ser-465/467 site (Smad2C) through TGF-β/TβRI, but also directly enhances the phosphorylation of Smad2 linker region at Ser-245/250/255 site (Smad2L), and then both of them collaborate to upregulate matrix metalloproteinase (MMP)-9-mediated cell migration and invasion of HCC.
|
26057631 |
2015 |
Liver carcinoma
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
We predict, based on gene expression data of patient samples, increased amounts of Smad2/3/4 proteins and Smad2 phosphorylation as hallmarks of hepatocellular carcinoma and experimentally verify this prediction.
|
29248373 |
2018 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Treatment with the herbal formula Songyou Yin inhibits epithelial-mesenchymal transition in hepatocellular carcinoma through downregulation of TGF-β1 expression and inhibition of the SMAD2/3 signaling pathway.
|
28454396 |
2017 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Curcumin downregulates the expression of Snail via suppressing Smad2 pathway to inhibit TGF-β1-induced epithelial-mesenchymal transitions in hepatoma cells.
|
29312546 |
2017 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
The aberrant location of expression and staining intensity of PTEN, PPM1A and P-Smad2 in HCC and their relationship might have an impact on the pathogenesis of HCC.
|
17729405 |
2007 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The abovementioned phenotypic changes are dependent on increases in epithelial-mesenchymal transition marker gene expression and transforming growth factor-β-Smad2/3 signaling activity in HCC.
|
28945217 |
2017 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, 3 of 10 human HCC tissues showed nuclear localization of Smad 2 and low mRNA levels of p15INK4B and antagonistic Smads but a high level of PAI-1.
|
10728705 |
2000 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Here, we investigated the functional role of the cyclin D1-dependent activation of Smad2/3 and Smad4 in hepatocellular carcinoma (HCC) CSCs and in HCC primary tumors.
|
28415588 |
2017 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry (IHC), quantitative real-time PCR (qRT-PCR) or Western blot analysis was used to detect TRIM52, p21, matrix metalloproteinase 2 (MMP2), protein phosphatase, Mg<sup>2+</sup>/Mn<sup>2+</sup> dependent 1A (PPM1A), p-Smad2/3 and Smad2/3 levels in HCC tissues and cell lines.
|
29898761 |
2018 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In clinical HCC samples, GP73 positively correlated with TGF-β1/Smad2, which was upregulated in HCC.
|
29365054 |
2018 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Compared with the control, miR-340 was significantly lower in the serum of the HCC patients (p < 0.01). miR-340 was lower in HCC tissues than in adjacent; however, DcR3, TGF-β1 and Smad2 were higher (p < 0.01).
|
29311025 |
2018 |