SMAD2, SMAD family member 2, 4087

N. diseases: 289; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.220 Biomarker disease BEFREE 1) CHI3L1 promoted cancer cell proliferation by regulating cell cycles; 2) CHI3L1 promoted cancer cell invasion and metastasis; 3) CHI3L1 regulate liver cancer potentially by regulating the TGF-β signaling pathways; 4) CHI3L1 has direct kinase activities or activate kinase to phosphorylate SMAD2, SMAD3. 30301907 2018
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.220 Biomarker disease BEFREE In conclusion, GDF11 has a tumor suppressor role in liver cancer, exerts its effects through Smad2/3 signaling and may serve as a novel tumor marker in liver cancer diagnosis. 29545874 2018
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.220 Biomarker disease RGD [Changes in TGF-beta1/Smads signaling pathway in rats with chemical hepatocarcinogenesis]. 18971187 2008