SMAD3, SMAD family member 3, 4088

N. diseases: 470; N. variants: 95
Disease: Crohn Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 Biomarker disease BEFREE Therefore, herbs-partitioned moxibustion combined with acupuncture can prevent intestinal epithelial mesenchymal transition by inhibiting abnormal expression of TGF<i>β</i>1, T<i>β</i>R2, Smad3, and Snail in the TGF-<i>β</i>1-Smad-Snail pathway in Crohn's disease. 31275422 2019
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 AlteredExpression disease BEFREE The high SMAD7 immunoreactivity and lack of p-SMAD3 expression in the LP suggests defective TGF-β signaling in the LP in EE similar to a previously reported SMAD7-mediated inflammatory pathway in refractory CD and Crohn's disease. 29415065 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease BEFREE SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease. 24461721 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease GWASDB Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease GWASCAT Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 Biomarker disease CTD_human Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010