|
Ureteral obstruction
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
An in vivo study revealed that petA protected against renal inflammation and fibrosis by reducing the infiltration of macrophages, inhibiting the expression of proinflammatory cytokines (interleukin-1β and tumour necrosis factor-α) and reducing extracellular matrix deposition (α-smooth muscle actin, collagen I and fibronectin) in the obstructed kidney of UUO mice; these changes were associated with suppression of Smad3 and NF-κB p65 phosphorylation.
|
31211499 |
2019 |
|
Ureteral obstruction
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Addition of the above compounds to culture media and their administration to UUO mice: (i) significantly attenuated epithelial-to-mesenchymal transition and extracellular matrix production in TGFβ1- and AngII-treated HK-2 cells and UUO mice by inhibiting Wnt/β-catenin pathway activation and Smad3 phosphorylation; (ii) selectively inhibited Smad3 phosphorylation by blocking the interaction of TGFBR1 with Smad3; and (iii) specifically inhibited Smad3 activation.
|
29679507 |
2018 |
|
Ureteral obstruction
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Further, results also demonstrated that HGF was upregulated and α-SMA was downregulated after p-SMAD3 knockdown in UUO mice.
|
30536302 |
2018 |
|
Ureteral obstruction
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Although type I TGF-β receptor (TGF-βRI), Smad2, Smad3, and Smad4 protein expression levels were markedly increased in mice with UUO, administration of PR-619 suppressed only Smad4 expression but not TGF-βRI, Smad2, or Smad3 expression.
|
30114247 |
2018 |
|
Ureteral obstruction
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
The TGF-β/Smads signaling activity analysis showed that SIS3 inhibited the phosphorylation of Smad3 but not Smad2 and decreased the protein level of TGF-β1, suggesting specific inhibition of the TGF-β/Smad3 pathway in UUO kidneys.
|
29555895 |
2018 |
|
Ureteral obstruction
|
0.390 |
Biomarker
|
phenotype |
CTD_human |
The antihelmenthic phosphate niclosamide impedes renal fibrosis by inhibiting homeodomain-interacting protein kinase 2 expression.
|
28318631 |
2017 |
|
Ureteral obstruction
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Compared to the wild types, fat-1 transgenics developed much less kidney fibrosis and inflammatory cell accumulation accompanied by less p-Akt (Ser473), p-Akt (Thr308), p-S6 and p-Smad3 in kidney tissues at day 7 after UUO.
|
28393852 |
2017 |
|
Ureteral obstruction
|
0.390 |
PosttranslationalModification
|
phenotype |
BEFREE |
<i>In vivo</i>, administration of BT173 decreased Smad3 phosphorylation and mitigated renal fibrosis and deposition of extracellular matrix in unilateral ureteral obstruction and Tg26 mouse models of renal fibrosis.
|
28220029 |
2017 |
|
Ureteral obstruction
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Treatment with nintedanib blocked UUO-induced phosphorylation of PDGFRβ, FGFR1, FGFR2, VEGFR2, and several Src family kinases including Src, Lck, Lyn as well as activation of signal transducer and activator of transcription-3 (STAT3), nuclear factor-κB (NF-κB), and Smad-3 in the kidney.
|
28646122 |
2017 |
|
Ureteral obstruction
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, DMF suppressed unilateral ureteral obstruction (UUO)-induced renal fibrosis and α-SMA, fibronectin and type 1 collagen expression in the obstructed kidneys from UUO mice, along with increased and decreased expression of Nrf2 and phospho-Smad3, respectively.
|
23056222 |
2012 |