|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The targeting of Smad4 may thus provide the sustainable loss of ATF3 expression that is needed to control breast cancer progression.
|
31082421 |
2019 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Information on clinical samples was obtained from The Cancer Genome Atlas data, in which the Pokemon mRNA levels showed a negative correlation with Smad4 levels in different subtypes of breast cancer in two independent datasets.
|
30941230 |
2019 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We revealed miR-574 could promote doxorubicin resistance of breast cancer MCF-7 cells via down-regulating SMAD4, thus providing a novel target for advancing breast cancer chemotherapy.
|
29565492 |
2018 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The results indicated that miR-224-5p/Smad4 regulating autophagy might be a novel regulatory network contributing to metastasis of breast cancer.
|
30389135 |
2018 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Combined markers of Smad4/GATA3 showed a superior performance compared to single markers for predicting RFS and OS in patients with breast cancer.
|
28288473 |
2017 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here the authors report the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.
|
28827661 |
2017 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Altogether, we demonstrate the vital interaction of USP9x and SMAD4 for governing TGFβ signaling and dyslipidemia-induced aberrant TGFβ activation during breast cancer metastasis.<i></i>.
|
28115363 |
2017 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Mutations in CREBBP and SMAD4 have only been occasionally reported in breast cancer.
|
27270325 |
2016 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We investigated SMAD4 expression in breast carcinoma samples of different histologic grades to evaluate the association between SMAD4 and outcome in breast cancer.
|
23975369 |
2014 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Bergapten induces ER depletion in breast cancer cells through SMAD4-mediated ubiquitination.
|
23053665 |
2012 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Several known regulators of breast cancer bone metastasis such as Smad4 and HIF1 were identified in our analysis.
|
22875853 |
2012 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Bridge-1 is expressed in human breast carcinomas: silencing of Bridge-1 decreases Smad2, Smad3 and Smad4 expression in MCF-7 cells, a human breast cancer cell line.
|
21448710 |
2011 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thus, it is currently unknown whether germline SMAD3 and SMAD4 mutations are involved in breast cancer predisposition.
|
21835029 |
2011 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Synergistic repression of estrogen receptor transcriptional activity by FHL2 and Smad4 in breast cancer cells.
|
20734429 |
2010 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
That linoleic acid induces PAI-1 expression in breast cancer cells through SMAD4 provides a novel insight into understanding the relationships between two migration-associated molecules, FFAs, and PAI-1.
|
19752858 |
2009 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Down-regulation and abnormal cellular distribution of Smad4 were associated with some ERalpha-positive infiltrating human breast carcinoma.
|
19943940 |
2009 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the chromosomal region where losses are frequent in breast, prostate, and other cancers, we detected a homozygous deletion of the SMAD4 gene in the MDA-MB-468 breast cancer cell line.
|
17523142 |
2007 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here, we have investigated the role of Smad4 in a cellular and mouse model for TGF-beta-induced breast cancer progression.
|
16489022 |
2006 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
As several breast cancer cell lines were shown to contain SMAD4 homozygous deletion, we sought to develop a reliable method to access such lesions in archived primary tumor specimens.
|
16627986 |
2006 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Smad4-induced apoptosis in ERalpha-positive breast cancer cells may explain the invasive nature of ERalpha-negative breast tumors, thereby providing a potential target for breast cancer intervention.
|
15886208 |
2005 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line.
|
15645498 |
2005 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
When Smad4 was expressed in Smad4-null breast carcinoma cell line MDA-MB-468 using the recombinant adenovirus, TGF-beta signaling was restored as determined by TGF-beta-dependent activity of plasminogen activator inhibitor 1 promoter and p21 expression.
|
12414627 |
2002 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Among 456 cases of human breast carcinoma assembled in tissue microarrays, the majority (92%) expressed Smad2, Smad2P, as well as Smad4, indicating their ability to proliferate within a microenvironment that contains bioactive TGF-beta.
|
11809701 |
2002 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
This observation contrasted with the absolute DPC4 dependence of TGFbeta responses in a breast cancer cell line studied in parallel.
|
10487520 |
1999 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The role of DPC4 in the transforming growth factor-beta (TGF-beta) receptor-mediated signal transduction cascade in human pancreatic, colon, and breast carcinoma cell lines has been investigated by a number of laboratories.
|
10415848 |
1999 |