Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
When assessed by a priori defined functional pathways, tumor growth factor β (TGFβ) signaling was associated with CRC risk (<i>P</i> ≤ 0.001), with most statistically significant genes being <i>SMAD7 (P<sub>BH</sub></i> = 0.008) and <i>SMAD3 (P<sub>BH</sub></i> = 0.008), and 18 SNPs in the vitamin D receptor (VDR) binding sites (<i>P</i> = 0.036).
|
31434255 |
2019 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
|
30529582 |
2019 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
|
31089142 |
2019 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this review, we summarize the available evidences about the role of Smad7 in both sporadic and colitis-associated CRC.
|
31052449 |
2019 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
As partial validation of our approach, a known CRC risk variant in SMAD7 (in both the TGF-β and WNT pathways: rs11874392) was associated with CRC risk in our data.
|
29986644 |
2018 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We found that two of the loci most strongly linked with colorectal cancer (CRC) risk, 8q24 (upstream of MYC) and 18q21 (in the intron of SMAD7), as well as 20q13 (in the intron of LAMA5), are tightly associated with the prognosis of rectal cancer patients.
|
29119627 |
2018 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer Risk.
|
30498395 |
2018 |
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
EGFR, SMAD7, and TGFBR2 are associated with CRC risk in patients with Lynch syndrome.
|
30275229 |
2018 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
|
30104761 |
2018 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
As regards the polymorphism of SMAD7, we found that CC (wild) genotype has high percentage in controls compared to CRC cases (36.1% vs 15.1%).
|
28374902 |
2018 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
|
29471430 |
2018 |
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
These findings delineate a novel mechanism by which Smad7 knockdown promotes CRC cell death.
|
28300830 |
2017 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population.
|
28467803 |
2017 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.
|
29228715 |
2017 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The two stage association studies showed that missense variant rs3764482 (c. 83C>T; p. rs3764482" genes_norm="4092">S28F) in the gene SMAD7 was consistently and significantly associated with CRC risk.
|
28218435 |
2017 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Eight miRSNPs (rs1804191, rs397768, rs41116 in APC; rs1137918, s227091, rs4585 in ATM; rs712, rs1137282, rs61764370 in KRAS; rs8674 in PARP1 and rs16950113 in SMAD7) were tested for their association with CRC risk in a case-control study (1111 cases and 1469 healthy controls).
|
29048575 |
2017 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The SMAD7 gene and specifically the allele C could be protective for colorectal cancer.
|
29084532 |
2017 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data suggest that SMAD7 rs4939827 and CHI3L1 rs4950928 SNPs have no significant association with CRC.
|
26779637 |
2016 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of colorectal cancer in Hispanics.
|
27207650 |
2016 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In summary, this large-scale meta-analysis indicated that SMAD7 polymorphisms (rs4464148, rs4939827, and rs12953717) correlate with CRC.
|
28070019 |
2016 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
|
26965516 |
2016 |
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
RHOA, SMAD2, SMAD4, SMAD5, SMAD6, BMPR1A, SMAD7 and MYC-, which thereby emerge as candidate genes to play an important role in CRC tumor metastasis.
|
27662660 |
2016 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
|
25990418 |
2015 |