|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It seems that REGγ impinges on repression of thyroid-specific genes and promotion of tumor malignancy in ATC cells by activating the TGF-β signal pathway via degradation of Smad7.
|
31243343 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, mice model analysis showed that microRNA-21 might regulate the growth of the transplanted tumors in mice by targeting smad family member 7.
|
31554487 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Up-regulation of circ-SMAD7 inhibits tumor proliferation and migration in esophageal squamous cell carcinoma.
|
30611100 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High expression of SMAD7 was positively associated with several features of tumor aggressiveness, for example, presence of ulceration (P < 0.001), higher tumor thickness (P < 0.001), and mitotic rate (P < 0.001), but not presence of regional or distant metastases.
|
30342000 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, adjacent oral cancer exposed to Tat-Smad7 did not show alterations in proliferation or direct DNA damage, but showed increased oxidative stress damage and apoptosis compared with tumors treated with vehicle.
|
30185419 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To assess the oncogenic risk of a potential Smad7-based therapy, we exposed K5.Smad7 skin to chemical carcinogenesis and found reduced myeloid leukocyte infiltration in tumors but not accelerated carcinogenesis compared with wild-type littermates.
|
30423327 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
When assessed by a priori defined functional pathways, tumor growth factor β (TGFβ) signaling was associated with CRC risk (<i>P</i> ≤ 0.001), with most statistically significant genes being <i>SMAD7 (P<sub>BH</sub></i> = 0.008) and <i>SMAD3 (P<sub>BH</sub></i> = 0.008), and 18 SNPs in the vitamin D receptor (VDR) binding sites (<i>P</i> = 0.036).
|
31434255 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these data support a novel role for SMAD7 as a tumor promoter in skin carcinogenesis where SMAD7 stimulates the DNA repair pathway and EGFR signaling activation.
|
30219864 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In fact, conditional Smad7 deletion led to sustained melanoma growth and at the same time promoted massive metastasis formation, a result consistent with data indicating that low SMAD7 levels in patient tumors are associated with a poor survival.
|
31039140 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Association of the infiltration of tumor-associated macrophages, expression of Smad7 protein and prognosis in oral squamous cell carcinoma.
|
30036733 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MiR-21-5p was highly expressed in the tumor tissues of NSCLC patients, and its expression was significantly correlated with the clinical classification of NSCLC patients (χ<sup>2</sup>=7.154, <i>P</i>=0.007), tumor size (χ<sup>2</sup>=4.372, <i>P</i>=0.037), differentiation (χ<sup>2</sup>=13.713, <i>P</i>=0.001), lymph node metastasis (χ<sup>2</sup>=5.101, <i>P</i>=0.024), distant metastasis (χ<sup>2</sup>=12.599, <i>P</i>=0.000), and TNM stage (χ<sup>2</sup>=6.344, <i>P</i>=0.012), whereas it was positively correlated with the expression of SMAD7 protein (<i>r</i>=0.669, <i>P</i><0.05).
|
30568467 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, Smad-7 protein expression in patients with HBV-associated liver cancer was higher than that in normal tumor-adjacent tissues.
|
28498453 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Activation of signal transducer and activator of transcription factor 3 signaling was found in Smad7-deficient mouse tumors and in patients with low tumoral SMAD7 expression as compared with surrounding tissue.
|
28134936 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The overexpression of HNF4α and Smad7 and the deletion of CD147 by lentiviral vectors jointly reprogrammed the expression profile of hepatocyte markers and attenuated malignant properties including proliferation, cell survival and tumor growth of HCC cells.
|
27041581 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SMAD7 might represent a target for inhibition of IL-1α induced tumor stroma interactions.
|
27473228 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In our cohort of 140 HCC patients, Smad7 transcripts were elevated in 41.4% of HCC samples as compared with adjacent tissue, with significant positive correlation to tumour size, whereas low Smad7 expression levels were significantly associated with worse clinical outcome.
|
25602745 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, the expression of SMAD2, SMAD3, and SMAD7 genes was reduced in the tumour, whilst no change was found in TGF-β expression.
|
25931269 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Smad7 maintains epithelial phenotype of ovarian cancer stem-like cells and supports tumor colonization by mesenchymal-epithelial transition.
|
25333457 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Consequently, the expressions of IL-10-responsive SOCS-3 and TGF-β-responsive Smad-7 were low in tumors but high in healthy skin.
|
25565012 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Second, we showed that Smad7 slows the growth of the primary tumor and increases mice survival.
|
25107916 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HER2 mRNA levels were significantly higher in tumor than in peritumor tissue (P = 0.028), and were positively correlated with MMP9 and Smad7 mRNA levels in tumor tissues.
|
24185685 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells.
|
24480808 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, our results demonstrated that miR-181c inhibits NB cell growth and metastasis-related traits through the suppression of Smad7, functioning as a tumor suppressor.
|
24345480 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Consistently, Smad7 mRNA and protein expression was also significantly reduced when EGFR activity was blocked by a specific tyrosine kinase inhibitor, AG1478, or in Stat3 knockdown tumors.
|
22751114 |
2013 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings suggest that individuals with this SMAD7 variant that develop CRC are more probably to have tumors with greater invasiveness and methylation of RUNX3, which potentially contributes to their poorer observed survival.
|
23104301 |
2013 |