|
Asthma, Occupational
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<b>Introduction:</b> Di-isocyanates TDI (toluene di-isocyanate), MDI (diphenylmethane di-isocyanate), and HDI (hexamethylene di-isocyanate) are the most common chemicals causing occupational asthma.
|
31649932 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.040 |
Biomarker
|
disease |
BEFREE |
<b>Objective</b> To compare the effectiveness of insulin pumps with multiple daily injections for adults with type 1 diabetes, with both groups receiving equivalent training in flexible insulin treatment.<b>Design</b> Pragmatic, multicentre, open label, parallel group, cluster randomised controlled trial (Relative Effectiveness of Pumps Over MDI and Structured Education (REPOSE) trial).<b>Setting</b> Eight secondary care centres in England and Scotland.<b>Participants</b> Adults with type 1 diabetes who were willing to undertake intensive insulin treatment, with no preference for pumps or multiple daily injections.
|
28360027 |
2017 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
MDI-222 enhanced electrically evoked AMPAR-mediated synaptic transmission in the anaesthetised rat at 10 mg/kg (administered intravenously) and did not significantly lower the seizure threshold in the pro-convulsant maximal electroshock threshold test (MEST) at any dose tested up to a maximum of 30 mg/kg (administered by oral gavage (p.o.)).
|
31766938 |
2020 |
|
Stage IV Breast Cancer AJCC v6 and v7
|
0.010 |
Biomarker
|
disease |
BEFREE |
A phase I study of the bispecific antibody MDX-H210 in combination with granulocyte colony-stimulating factor (G-CSF) was performed in stage IV breast carcinoma patients, overexpressing HER-2/neu.
|
14676800 |
2003 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.040 |
Biomarker
|
disease |
BEFREE |
A1C = hemoglobin A1C ANOVA = analysis of variance CGM = continuous glucose monitoring CSII = continuous subcutaneous insulin infusion MDI = multiple daily injection T1D = type 1 diabetes.
|
28156154 |
2017 |
|
Absence of sensation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Compared with the DI group the MDI group had higher success rates of complete sensory block of the ulnar nerve (93 vs 67%, P = 0.002) and complete anaesthesia (80 vs 56%, P = 0.014) at 15 min, whereas the average performance time was significantly longer (5.08 ± 1.41 vs 4.10 ± 0.64 min, P < 0.001) and the number of needle passes was significantly higher (4.40 ± 1.14 vs 2.87 ± 0.79, P < 0.001).
|
27798452 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.040 |
Biomarker
|
disease |
BEFREE |
CSII seems to produce a small improvement in HbA1c in patients with type 1 diabetes inadequately controlled with MDI.
|
30945047 |
2019 |
|
Cerebral Palsy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Definitely abnormal GM were associated with reduced MDI (-12.0, 95% CI -23.2; -0.87) and identified all children with cerebral palsy (CP) in the sample of GMA at 3 months only.
|
28113095 |
2017 |
|
Bipolar Disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Genetic factors are of major aetiological importance in Bipolar Affective Disorder (BPAD type I and II).
|
8980009 |
1995 |
|
MAJOR AFFECTIVE DISORDER 2
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genetic factors are of major aetiological importance in Bipolar Affective Disorder (BPAD type I and II).
|
8980009 |
1995 |
|
MAJOR AFFECTIVE DISORDER 1
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genetic factors are of major aetiological importance in Bipolar Affective Disorder (BPAD type I and II).
|
8980009 |
1995 |
|
MAJOR AFFECTIVE DISORDER 4
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genetic factors are of major aetiological importance in Bipolar Affective Disorder (BPAD type I and II).
|
8980009 |
1995 |
|
MAJOR AFFECTIVE DISORDER 6
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genetic factors are of major aetiological importance in Bipolar Affective Disorder (BPAD type I and II).
|
8980009 |
1995 |
|
MAJOR AFFECTIVE DISORDER 7
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genetic factors are of major aetiological importance in Bipolar Affective Disorder (BPAD type I and II).
|
8980009 |
1995 |
|
MAJOR AFFECTIVE DISORDER 8
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genetic factors are of major aetiological importance in Bipolar Affective Disorder (BPAD type I and II).
|
8980009 |
1995 |
|
MAJOR AFFECTIVE DISORDER 9
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genetic factors are of major aetiological importance in Bipolar Affective Disorder (BPAD type I and II).
|
8980009 |
1995 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Immunohistochemical analyses of tumour biopsies in individual patients documented infiltration of monocytes and PMN after MDX-H210 infusion.
|
14676800 |
2003 |
|
Cardiomyopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, this study demonstrated that allogeneic WT-MPC-Exo transplantation transiently restored dystrophin gene expression and improved cardiac function in MDX mice, suggesting that allogenic exosomal delivery may serve as an alternative treatment for cardiomyopathy of DMD.
|
30155598 |
2018 |
|
alcohol effect
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In mediation models of 6 month cognitive and motor development with reference to Barron and Kenney in 1986, GA significantly mediated alcohol effects (MDI: Z = -2.64, p < .008; PDI: Z = -2.35, p < .02) although PAE independently affected both outcomes (MDI: t = -5.6, p < .000; PDI: t = -3.19, p < .002).
|
30378744 |
2019 |
|
Hypoglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inclusion criteria were: type 2 diabetes, 18-75 years of age, glycosylated hemoglobin (HbA1c) more than 6.5% (48 mmol/mol) on multiple doses of insulin (MDI > four injections per day) or more than 100 units of insulin/day, wide glycemic excursions, and intractable hypoglycemia.We identified a total of 13 patients.
|
30410846 |
2018 |
|
Bipolar Disorder
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Individuals with BPAD presented higher levels of A. actinomycetemcomitans and P. gingivalis, suggesting that periodontitis could be a co-morbidity frequently found in individuals with BAPD.
|
30207388 |
2019 |
|
MAJOR AFFECTIVE DISORDER 2
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Individuals with BPAD presented higher levels of A. actinomycetemcomitans and P. gingivalis, suggesting that periodontitis could be a co-morbidity frequently found in individuals with BAPD.
|
30207388 |
2019 |
|
MAJOR AFFECTIVE DISORDER 1
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Individuals with BPAD presented higher levels of A. actinomycetemcomitans and P. gingivalis, suggesting that periodontitis could be a co-morbidity frequently found in individuals with BAPD.
|
30207388 |
2019 |
|
MAJOR AFFECTIVE DISORDER 4
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Individuals with BPAD presented higher levels of A. actinomycetemcomitans and P. gingivalis, suggesting that periodontitis could be a co-morbidity frequently found in individuals with BAPD.
|
30207388 |
2019 |
|
MAJOR AFFECTIVE DISORDER 6
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Individuals with BPAD presented higher levels of A. actinomycetemcomitans and P. gingivalis, suggesting that periodontitis could be a co-morbidity frequently found in individuals with BAPD.
|
30207388 |
2019 |