MAFG, MAF bZIP transcription factor G, 4097

N. diseases: 18; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.010 Biomarker disease BEFREE In summary, this study unveiled the MAFG-AS1/miR-744-5p/MAFG axis in LUAD, providing a potent and promising therapeutic target for LUAD patients. 31211984 2019
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma
0.010 Biomarker disease BEFREE Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. 29733835 2018
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.010 GeneticVariation disease BEFREE Sequencing MAFG locus, we identified 30 novel SNPs and two were associated with either gene expression or lung cancer status among smokers. 20689807 2010
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma
0.010 AlteredExpression disease BEFREE Expression of MAFG increases in cells and tissues with cholestasis, as well as in human cholangiocarcinoma and HCC specimens; high expression levels correlate with tumor progression and reduced survival time. 29733835 2018
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.020 AlteredExpression disease BEFREE We have identified that PHB1, down-regulated in most human HCC and CCA, heterodimerizes with MAX to repress the E-box and positively regulates MAT1A while suppressing c-MYC, MAFG, and c-MAF expression; in mice, reduced PHB1 expression predisposes to the development of cholestasis-induced CCA.(Hepatology 2017;65:1249-1266). 27981602 2017
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.020 AlteredExpression disease BEFREE SAMe and UDCA reduce expression of MAFG in response to cholestasis, by shared and distinct mechanisms. 29733835 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.020 GeneticVariation disease BEFREE MAFG mediates CIMP in BRAF-mutant colorectal cancer. 25367952 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.020 GeneticVariation disease BEFREE Through an RNAi screen, here we identify the transcriptional repressor MAFG as the pivotal factor required for MLH1 silencing and CIMP in CRCs containing BRAF(V600E). 25219500 2014
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.010 AlteredExpression disease BEFREE High levels of MAFG in HCC samples correlated with hepatitis B, vascular invasion, and shorter survival times of patients. 29733835 2018
CUI: C0008372
Disease: Intrahepatic Cholestasis
Intrahepatic Cholestasis
0.300 Biomarker disease CTD_human Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice. 20146260 2010
Liver and Intrahepatic Biliary Tract Carcinoma
0.010 Biomarker disease BEFREE Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. 29733835 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.010 AlteredExpression disease BEFREE Expression of MAFG increases in cells and tissues with cholestasis, as well as in human cholangiocarcinoma and HCC specimens; high expression levels correlate with tumor progression and reduced survival time. 29733835 2018
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.010 AlteredExpression group BEFREE Expression of MAFG and MAT2A increased, and expression of MAT1A decreased, in diethylnitrosamine-induced liver tumors in mice. 29733835 2018
Malignant neoplasm of colon and/or rectum
0.010 GeneticVariation disease BEFREE MAFG mediates CIMP in BRAF-mutant colorectal cancer. 25367952 2014
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.010 Biomarker disease BEFREE Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. 29733835 2018
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.010 GeneticVariation disease BEFREE Sequencing MAFG locus, we identified 30 novel SNPs and two were associated with either gene expression or lung cancer status among smokers. 20689807 2010
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic
0.010 Biomarker disease BEFREE These novel data suggest an association between MAFF and MAFG and the development of CML. 24118457 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.020 AlteredExpression group BEFREE Potential tumor suppressors (FoxA3 and Onecut1) and oncogenes (MAFG and SSX1) were functionally validated. 24798046 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.020 AlteredExpression group BEFREE We also investigated whether obeticholic acid (OCA), an farnesoid X receptor agonist, affects MAFG expression and how it contributes to tumor growth in mice. 29733835 2018
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.010 GeneticVariation disease BEFREE Sequencing MAFG locus, we identified 30 novel SNPs and two were associated with either gene expression or lung cancer status among smokers. 20689807 2010
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.010 AlteredExpression phenotype BEFREE Expression of MAFG increases in cells and tissues with cholestasis, as well as in human cholangiocarcinoma and HCC specimens; high expression levels correlate with tumor progression and reduced survival time. 29733835 2018