Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, this study unveiled the MAFG-AS1/miR-744-5p/MAFG axis in LUAD, providing a potent and promising therapeutic target for LUAD patients.
|
31211984 |
2019 |
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.
|
29733835 |
2018 |
Carcinoma of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sequencing MAFG locus, we identified 30 novel SNPs and two were associated with either gene expression or lung cancer status among smokers.
|
20689807 |
2010 |
Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of MAFG increases in cells and tissues with cholestasis, as well as in human cholangiocarcinoma and HCC specimens; high expression levels correlate with tumor progression and reduced survival time.
|
29733835 |
2018 |
Cholestasis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We have identified that PHB1, down-regulated in most human HCC and CCA, heterodimerizes with MAX to repress the E-box and positively regulates MAT1A while suppressing c-MYC, MAFG, and c-MAF expression; in mice, reduced PHB1 expression predisposes to the development of cholestasis-induced CCA.(Hepatology 2017;65:1249-1266).
|
27981602 |
2017 |
Cholestasis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SAMe and UDCA reduce expression of MAFG in response to cholestasis, by shared and distinct mechanisms.
|
29733835 |
2018 |
Colorectal Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
MAFG mediates CIMP in BRAF-mutant colorectal cancer.
|
25367952 |
2014 |
Colorectal Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Through an RNAi screen, here we identify the transcriptional repressor MAFG as the pivotal factor required for MLH1 silencing and CIMP in CRCs containing BRAF(V600E).
|
25219500 |
2014 |
Hepatitis B
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High levels of MAFG in HCC samples correlated with hepatitis B, vascular invasion, and shorter survival times of patients.
|
29733835 |
2018 |
Intrahepatic Cholestasis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice.
|
20146260 |
2010 |
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.
|
29733835 |
2018 |
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of MAFG increases in cells and tissues with cholestasis, as well as in human cholangiocarcinoma and HCC specimens; high expression levels correlate with tumor progression and reduced survival time.
|
29733835 |
2018 |
Liver neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Expression of MAFG and MAT2A increased, and expression of MAT1A decreased, in diethylnitrosamine-induced liver tumors in mice.
|
29733835 |
2018 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MAFG mediates CIMP in BRAF-mutant colorectal cancer.
|
25367952 |
2014 |
Malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.
|
29733835 |
2018 |
Malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sequencing MAFG locus, we identified 30 novel SNPs and two were associated with either gene expression or lung cancer status among smokers.
|
20689807 |
2010 |
Myeloid Leukemia, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
These novel data suggest an association between MAFF and MAFG and the development of CML.
|
24118457 |
2014 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Potential tumor suppressors (FoxA3 and Onecut1) and oncogenes (MAFG and SSX1) were functionally validated.
|
24798046 |
2014 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We also investigated whether obeticholic acid (OCA), an farnesoid X receptor agonist, affects MAFG expression and how it contributes to tumor growth in mice.
|
29733835 |
2018 |
Primary malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sequencing MAFG locus, we identified 30 novel SNPs and two were associated with either gene expression or lung cancer status among smokers.
|
20689807 |
2010 |
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of MAFG increases in cells and tissues with cholestasis, as well as in human cholangiocarcinoma and HCC specimens; high expression levels correlate with tumor progression and reduced survival time.
|
29733835 |
2018 |