MAOA, monoamine oxidase A, 4128

N. diseases: 300; N. variants: 15
Disease: Unipolar Depression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE MAO-A gene polymorphisms are associated with major depression and sleep disturbance in males. 15486489 2004
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Our results suggest that MAOA gene variation may modulate the expression of some clinical aspects of severe mood disorders, especially in females, and support the existence of a genetic and aetiologic heterogeneity underlying the diagnoses of bipolar disorder and major depression. 15564894 2004
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE We conclude that genetic variation in the MAOA gene may affect the course of major depression by disrupting cortico-limbic connectivity. 18544183 2009
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Therefore, in the present study, genetic variation in the MAO-A gene was investigated for its influence on complicated grief in major depression. 18337637 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Our meta-analysis suggests a significant association of the MAOA gene with major depressive disorder and BPD within specific groups, indicating that these three polymorphisms of the MAOA gene may be associated with mood disorders by sex and ethnicity. 20010318 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE MAOA gene polymorphisms and response to mirtazapine in major depression. 19382113 2009
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Association of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorder. 21605465 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE The present study fails to demonstrate that the genetic polymorphisms of MAOA-VNTR and TPH-A218C affect the antidepressant effect of fluvoxamine in Japanese patients with major depressive disorder. 12502014 2002
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE We investigated the polymorphisms of the MAO-A gene, which may be related to enzyme activity (T/941/G, A/1609/G), with amino-acid change (A/1609/G), in Japanese patients with bipolar disorder patients (n = 132), unipolar major depression (n = 43), or schizophrenia (n = 95), and controls (n = 169). 9807650 1998
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Thus, our data suggest that an excess of high-activity MAO-A gene promoter alleles resulting in an elevated MAO-A activity is a risk factor for major depressive disorder in females.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:801-803, 2000. 11121185 2000
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE The present results suggest that high-activity MAO-A genotypes possibly by consecutively decreased serotonin and/or norepinephrine availability negatively influence antidepressant treatment response during the first six weeks of pharmacological treatment in female patients with Major Depression. 17884271 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response. 15956990 2005
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE This study was conducted to detect a possible association of a T941G single nucleotide polymorphism (SNP) in the monoamine oxidase A (MAOA) gene with generalized anxiety disorder (GAD), panic disorder (PD), or major depression (MD). 12555227 2003
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE A cis-phase interaction study of genetic variants within the MAOA gene in major depressive disorder. 20691428 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE There was no significant genotypic or allelic association, suggesting that the functional VNTR polymorphism in the MAOA gene is unlikely to play a major role in the pathogenesis of bipolar disorder or unipolar depression. 10483059 1999
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder. 19593178 2009
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE The MAOA T941G polymorphism and short-term treatment response to mirtazapine and paroxetine in major depression. 17192957 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Major depressive disorder is a mediating factor between the monoamine oxidase A promoter polymorphism and telomeric length. 17417064 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET Genetic risk factors for depression in Alzheimer`s disease patients. 23157339 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease BEFREE We conclude that the Gene x Environment interplay at this locus (MAOA) contributes to both symptoms of ASPD and MD and that careful specification of child maltreatment may be essential if genetic association research is to produce replicable results. 20175604 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease BEFREE By including individuals varying in their degree of susceptibility to MD, we showed evidence of interactions between 5-HTT and MD susceptibility in baseline cortisol, and between MAOA and MD susceptibility in baseline ACTH measures, indicating a role for these genotypes in stable-state endocrine regulation. 17453062 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression. 23221997 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease BEFREE The reduction of R1, a novel repressor protein for monoamine oxidase A, in major depressive disorder. 21654740 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET Low-activity MAOA genotype buffered against symptoms of dysthymia, major depressive disorder, and alcohol abuse for sexually abused white participants. 22030358 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease BEFREE Monoamine oxidase A and B (MAOA and MAOB) appear to be involved in the pathogenesis of Major Depression, and vulnerability of Major Depression is associated with personality traits relating to positive and negative affect. 19657584 2009