|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
But the co-occurrence among outcomes between exposures to chemical stressors, non-chemical stressors, and the low activity MAOA genotype suggest that mental illness in children may be influenced by multiple interacting factors.
|
31706600 |
2020 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Monoamine oxidase-A (MAOA) metabolises monoamines and is implicated in the pathophysiology of psychiatric disorders.
|
29667298 |
2019 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The results of association rules showed that CCK, MAOA, and 5-HTT are the most closely related.We used text mining technology to analyze genes related to mental disorders to further summarize and clarify the relationships between mental disorders and genes as well as identify potential relationships, providing a foundation for future experiments.
|
31626105 |
2019 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
However, MAO-A inhibitors, which directly acts on MAO-A protein, have limited use due to their adverse effects. microRNAs (miRNAs) are 18-22 nucleotide long, small non-coding RNAs, which have recently emerged as regulators of protein levels that could potentially be new therapeutic targets for psychiatric disorders.
|
30271325 |
2018 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Monoamine oxidase A (MAO-A) plays an important role in various functions of the brain, such as regulation of mood, anxiety and aggression, and dysregulation of MAO-A is observed in stress-related psychiatric disorders.
|
30687104 |
2018 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Childhood physical abuse (PA) and sexual abuse (SA) interact with monoamine oxidase A (MAOA) gene polymorphism to modify risk for mental disorders.
|
29600412 |
2018 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Previous studies have showed associations of serotonin transporter (5-HTT) and monoamine oxidase A (MAOA) with behavioral and psychiatric disorders.
|
30126429 |
2018 |
|
Mental disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Monoamine oxidase A, an X-linked gene, is one example of a molecular target linked to brain activity in psychiatric illness.
|
29746646 |
2018 |
|
Mental disorders
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Altered MAOA gene DNA methylation emerges as a possible pathogenetically relevant epigenetic mechanism in mental disorders.
|
30242487 |
2018 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Collectively, we confirmed that MAOA is a risk gene for psychiatric disorders, and our results provide useful information toward a better understanding of genetic mechanism involving MAOA underlying risk of complex psychiatric disorders.
|
26227907 |
2016 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Monoamine oxidase A (MAOA), a catecholamine neurotransmitter degrading enzyme, is closely associated with neurological and psychiatric disorders.
|
24607627 |
2014 |
|
Mental disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In women, low expression of MAOA (MAOA-L) was related significantly to greater happiness (0.261 SD increase with one L-allele, 0.522 SD with two L-alleles, P=0.002) after adjusting for the potential effects of age, education, household income, marital status, employment status, mental disorder, physical health, relationship quality, religiosity, abuse history, recent negative life events and self-esteem use in linear regression models.
|
22885141 |
2013 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A functional promoter polymorphism in the monoamine oxidase A (MAOA) gene has been implicated in neuropsychiatric disorders and also moderates the association between early-life stress and mental disorders, which often co-occur with cardiovascular disease.
|
23723362 |
2013 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
CTD_human |
Influence of prenatal iron deficiency and MAOA genotype on response to social challenge in rhesus monkey infants.
|
22340208 |
2012 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We evaluated the association of the variable number tandem repeat of the MAOA promoter with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, ASP disorder (ASPD) traits in a community sample of 435 participants from the Hopkins Epidemiology of Personality Disorders Study.
|
21295226 |
2011 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Polymorphisms of isoforms MAOA and MAOB have been implicated in the etiology of mental disorders such as schizophrenia.
|
21978760 |
2011 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This review tries to cover the literature on the impact of gene variants implicated in psychiatric disorders on serotonin, dopamine, and MAO-A radioligand binding in living humans.
|
20399868 |
2010 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
LHGDN |
[Genetic polymorphism of a MAO in mental disorders].
|
18046979 |
2008 |
|
Mental disorders
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
We conclude that methylation of MAOA may play a significant role in common psychiatric illness and that further examination of epigenetic processes at this locus is in order.
|
18454435 |
2008 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
These findings in a different culture further support the influence of the MAOA-uVNTR in psychiatric disorders.
|
16526025 |
2006 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
By conferring allele-specific transcriptional activity on the monoamine oxidase A (MAOA) gene in humans, length variation of a repetitive sequence [(variable number of tandem repeat (VNTR)] in the MAOA promoter influences a constellation of personality traits related to aggressive and antisocial behavior and increases the risk of neurodevelopmental and psychiatric disorders.
|
16436187 |
2006 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the present study, the association between the monoamine oxidase A variable number tandem repeat polymorphism and personality traits assessed by the Temperament and Character Inventory was examined in 324 Japanese volunteers without psychiatric disorders.
|
16538181 |
2006 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Monoamine oxidase type A (MAOA) has been implicated to be part of mechanisms underlying human temperament and psychiatric disorders.
|
12566936 |
2002 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
We then examined genetic polymorphisms in four candidate genes (DRD4, DAT, COMT and MAOA) that have been shown to contribute to the risk of developing various psychiatric disorders where attention is disrupted.
|
12366871 |
2002 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To investigate the possible influence of the allelic variants of the MAOA gene-linked polymorphic region (MAOA-LPR) on the genetic predisposition to psychiatric disorders, we have performed a case-control association study.
|
11304831 |
2001 |