MAOA, monoamine oxidase A, 4128

N. diseases: 48; N. variants: 6
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET Hypomethylation of MAOA's first exon region in depression: a replication study. 25623016 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET For example, MAO-A mRNA is repressed across cancers, yet MAO-A protein and levels of serotonin, a substrate of MAO-A implicated in depression, are paradoxically increased in malignancies, including breast cancer. 25152370 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET The frontal abnormality of patients with depression had certain 5-HT genetic basis, and 5-HT2A receptor CC allele and MAOA-H genotype had synergistic effect on the activity abnormality when recognizing negative emotion in right frontal middle gyrus of patients with depression. 24314147 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET Monoamine oxidase A (MAOA), a mitochondrial enzyme involved in the degradation of amines, has been reported to be associated with aggression, impulsivity, depression, and mood changes. 24652311 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET Molecular genetic studies point to potential risk loci of psychotic depression shared with schizoaffective disorder (1q42, 22q11, 19p13), depression, bipolar disorder, and schizophrenia (6p, 8p22, 10p13-12, 10p14, 13q13-14, 13q32, 18p, 22q11-13) and several vulnerability genes possibly contributing to an increased risk of psychotic symptoms in depression (eg, BDNF, DBH, DTNBP1, DRD2, DRD4, GSK-3beta, MAO-A). 23512949 2013