MAOA, monoamine oxidase A, 4128

N. diseases: 300; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.320 Biomarker disease BEFREE This study supports a potential therapeutic use for MAO-A inhibitors in the treatment of depression and anxiety in patients with HD. 26825854 2016
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.320 GeneticVariation disease BEFREE We show that cognitive impairment and psychiatric symptoms in HD are modified by polymorphisms in the monoamine oxidase A (MAOA) and catechol-O-methyltransferase (COMT) genes and by the 4p16.3 B haplotype. 26081309 2016
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.320 Biomarker disease CTD_human We therefore measured, with anatomical resolution, MAO-A and -B activities in 5 cases of HD (severity grades 1-3) and age-matched controls by quantitative enzyme radioautography using radiolabeled enzyme inhibitors (3)H-Ro 41-1049 and (3)H-lazabemide, respectively, as high-affinity ligands in vitro.MAO-A was increased significantly (ca. 21075085 2011