MAOA, monoamine oxidase A, 4128

N. diseases: 48; N. variants: 6
Disease: clinical depression ×
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2362914
Disease: clinical depression
clinical depression 		0.310 Biomarker disease PSYGENET Given that carriers of certain Alzheimer's disease (AD)-related PS-1 variants are predisposed to clinical depression and that depression has been historically associated with the mitochondrial enzyme, monoamine oxidase-A (MAO-A), we investigated cortical MAO-A function in the AD-related PS-1(M146V) knock-in mouse. 22045496 2012
CUI: C2362914
Disease: clinical depression
clinical depression 		0.310 Biomarker disease PSYGENET Finally, we demonstrate that the two PS-1 variants reported to be associated with an increased incidence of clinical depression [e.g., A431E and L235V] both induce MAO-A activity in HT-22 cells. 21373759 2011