MAOA, monoamine oxidase A, 4128

N. diseases: 48; N. variants: 6
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0796275
Disease: Brunner Syndrome
Brunner Syndrome 		0.910 Biomarker disease GENOMICS_ENGLAND New insights into Brunner syndrome and potential for targeted therapy. 25807999 2016
CUI: C0796275
Disease: Brunner Syndrome
Brunner Syndrome 		0.910 Biomarker disease GENOMICS_ENGLAND The International Working Group on Neurotransmitter related Disorders (iNTD): A worldwide research project focused on primary and secondary neurotransmitter disorders. 27830117 2016
CUI: C0796275
Disease: Brunner Syndrome
Brunner Syndrome 		0.910 Biomarker disease GENOMICS_ENGLAND It is the case of the X-linked gene encoding monoamine oxidase A (MAOA), for which only one nonsense mutation has been identified in Brunner syndrome, characterized in a single family by mild non-dysmorphic ID and impulsive, violent and aggressive behaviors. 24169519 2014
CUI: C0796275
Disease: Brunner Syndrome
Brunner Syndrome 		0.910 Biomarker disease GENOMICS_ENGLAND It is the case of the X-linked gene encoding monoamine oxidase A (MAOA), for which only one nonsense mutation has been identified in Brunner syndrome, characterized in a single family by mild non-dysmorphic ID and impulsive, violent and aggressive behaviors. 24169519 2014
CUI: C0796275
Disease: Brunner Syndrome
Brunner Syndrome 		0.910 GermlineCausalMutation disease ORPHANET It is the case of the X-linked gene encoding monoamine oxidase A (MAOA), for which only one nonsense mutation has been identified in Brunner syndrome, characterized in a single family by mild non-dysmorphic ID and impulsive, violent and aggressive behaviors. 24169519 2014
CUI: C0796275
Disease: Brunner Syndrome
Brunner Syndrome 		0.910 GermlineCausalMutation disease ORPHANET Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. 8211186 1993
CUI: C0796275
Disease: Brunner Syndrome
Brunner Syndrome 		0.910 Biomarker disease CTD_human
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.500 Biomarker disease CTD_human We replicated and extended a previously reported association between autism severity and a functional polymorphism in the monoamine oxidase A (MAOA) promoter region, MAOA-uVNTR, in a sample of 119 males, aged 2-13 years, with autism spectrum disorder from simplex families. 20573161 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.500 Biomarker disease CTD_human In this study we genotyped the MAOA promoter polymorphism in a group of 29 males (age 2-3 years) with autism and a group of 39 healthy pediatric controls for whom brain MRI data was available. 18361446 2008
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.500 Biomarker disease CTD_human We conclude that functional MAOA-uVNTR alleles may act as a genetic modifier of the severity of autism in males. 12919132 2003
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.400 Biomarker disease PSYGENET Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. 25660313 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease PSYGENET Hypomethylation of MAOA's first exon region in depression: a replication study. 25623016 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Hypomethylation of MAOA's first exon region in depression: a replication study. 25623016 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET 94 patients of Caucasian descent with major depressive disorder (f = 61; DSM-IV) were analyzed for DNA methylation status at 43 MAO-A CpG sites via direct sequencing of sodium bisulfite treated DNA extracted from blood cells. 24809685 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease PSYGENET 94 patients of Caucasian descent with major depressive disorder (f = 61; DSM-IV) were analyzed for DNA methylation status at 43 MAO-A CpG sites via direct sequencing of sodium bisulfite treated DNA extracted from blood cells. 24809685 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease PSYGENET The frontal abnormality of patients with depression had certain 5-HT genetic basis, and 5-HT2A receptor CC allele and MAOA-H genotype had synergistic effect on the activity abnormality when recognizing negative emotion in right frontal middle gyrus of patients with depression. 24314147 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease PSYGENET Monoamine oxidase A (MAOA), a mitochondrial enzyme involved in the degradation of amines, has been reported to be associated with aggression, impulsivity, depression, and mood changes. 24652311 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease PSYGENET For example, MAO-A mRNA is repressed across cancers, yet MAO-A protein and levels of serotonin, a substrate of MAO-A implicated in depression, are paradoxically increased in malignancies, including breast cancer. 25152370 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET For example, MAO-A mRNA is repressed across cancers, yet MAO-A protein and levels of serotonin, a substrate of MAO-A implicated in depression, are paradoxically increased in malignancies, including breast cancer. 25152370 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET The frontal abnormality of patients with depression had certain 5-HT genetic basis, and 5-HT2A receptor CC allele and MAOA-H genotype had synergistic effect on the activity abnormality when recognizing negative emotion in right frontal middle gyrus of patients with depression. 24314147 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Monoamine oxidase A (MAOA), a mitochondrial enzyme involved in the degradation of amines, has been reported to be associated with aggression, impulsivity, depression, and mood changes. 24652311 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis. 25073638 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET The aim of this study was to investigate the associations between the exonic single nucleotide polymorphisms (SNPs) of the MAOA gene located on the X chromosome and schizophrenia. 24510409 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.400 Biomarker group PSYGENET Analysis did not show any statistically significant differences in the mean levels of anxiety, and mood disorders in women in relation to genotypes of the 5-HTTLPR (SLC6A4) polymorphism and the 30-bp VNTR polymorphism in the MAO A promoter region. 25547397 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.400 Biomarker disease PSYGENET Therefore, we examined whether the DRD2TaqIA and MAOA-uVNTR gene polymorphisms are susceptibility factors for alcoholism comorbid with bipolar disorder (ALC+BP) in Han Chinese in Taiwan. 23044341 2013